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Key Documents

Inne dokumenty

T0667

Sigma-Aldrich

Trimethoprim lactate salt

≥98%

Synonim(y):

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt

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About This Item

Wzór empiryczny (zapis Hilla):
C14H18N4O3 · C3H6O3
Numer CAS:
23256-42-0
Masa cząsteczkowa:
380.40
Numer WE:
245-533-1
Numer MDL:
MFCD00171722
Kod UNSPSC:
51285203
Identyfikator substancji w PubChem:
329826610
NACRES:
NA.85

Poziom jakości

200

Próba

≥98%

Postać

powder

warunki przechowywania

(Keep container tightly closed in a dry and well-ventilated place.)

kolor

white

rozpuszczalność

H2O: soluble 20 mg/mL

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Tryb działania

DNA synthesis | interferes
enzyme | inhibits

temp. przechowywania

2-8°C

ciąg SMILES

CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)

Klucz InChI

IIZVTUWSIKTFKO-UHFFFAOYSA-N

Opis ogólny

Chemical structure: pyrimidine

Zastosowanie

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

Działania biochem./fizjol.

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesHealth hazard
GHS06,GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H301,H361d

Zwroty wskazujące środki ostrożności

P202 - P264 - P280 - P301 + P310 - P405 - P501

Klasyfikacja zagrożeń

Acute Tox. 3 Oral - Repr. 2

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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