SRP5262

SETMAR, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonim(y): METNASE
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• rekombinowane: expressed in baculovirus infected Sf9 cells
• Próba: ≥70% (SDS-PAGE)
• Postać: buffered aqueous glycerol solution
• masa cząsteczkowa: 66-69 kDa
• numer dostępu NCBI: BC011635
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... SETMAR(6419)

Opis

Opis ogólny

SETMAR or SET domain and mariner transposase fusion gene is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA by opening chromatin and facilitating joining of DNA ends. SETMAR has histone methyltransferase activity and methylates ′Lys-4′ and ′Lys-36′ of histone H3. SETMAR also has DNA nicking activity and may play a role in DNA repair. Human Pso4 forms a stable complex with SETMAR that regulates Metnase function in DNA repair. SETMAR has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5′-terminal inverted repeats (TIRs) of the Hsmar1 element.

Postać fizyczna

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Uwaga dotycząca przygotowania

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable