SRP4928
Lipocalin-2 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonim(y):
25 kDa α-2-microglobulin-related subunit of MMP-9, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, p25
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About This Item
Kod UNSPSC:
12352200
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in E. coli
Próba
≥95% (HPLC)
≥95% (SDS-PAGE)
Formularz
lyophilized
masa cząsteczkowa
~20 kDa
opakowanie
pkg of 50 μg
metody
activity assay: suitable
zanieczyszczenia
endotoxin, tested
numer dostępu NCBI
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... LCN2(3934)
Opis ogólny
Research area: Cell signaling. The gene LCN2 (lipocalin 2) is mapped to human chromosome 9q34. LCN2, a secreted glycoprotein, is an adipokine. It is expressed by many cells, such as respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells, and cardiomyocytes. LCN2 belongs to the lipocalin family. LCN2 consists of the lipid binding domain that binds to small hydrophobic molecules and the ligand binding cavity that binds to bacterial and mammalian proteins called siderophores.
Zastosowanie
LCN2 (lipocalin 2)-human has been used in the cell proliferation assay.It has also been used in conductometric immunoassay in renal carcinoma cells.
Działania biochem./fizjol.
LCN2 (lipocalin 2) potentially connects obesity and its related adipose inflammation. LCN2 has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. It is an early marker of acute kidney injury, cardiovascular diseases, lupus nephritis, and intestinal inflammation. LCN2 is upregulated in humans with heart failure. It can associate with MMP9 (matrix metalloproteinase-9) and controls its stability. Changes in the expression of LCN2 are associated with many cancers, including breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder, and kidney cancers.LCN2 acts as a pleiotropicmolecule and plays a role in several pathophysiological and physiologicalactivities including immune response, inflammation, metabolic homeostasis, andinfection.
Postać fizyczna
Lyophilized with no additives.
Rekonstytucja
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Certyfikaty analizy (CoA)
Lot/Batch Number
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Gordon P Otto et al.
PloS one, 10(4), e0124429-e0124429 (2015-04-22)
Acute kidney injury (AKI) during sepsis is common and underestimated. Plasma neutrophil gelatinase-associated lipocalin (plasma-NGAL) is discussed as new biomarker for AKI diagnosis, but during inflammation its function and diagnostic impact remain unclear. The association between plasma-NGAL and inflammatory markers
Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-?B inhibitor BRM270 in a xenograft model of lung adenocarcinoma.
International Journal of Oncology, 48, 84-98 (2016)
Guoliang Wang et al.
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Wu B
Scientific Reports, 4, doi: 10-doi: 10 (2014)
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.
Catalan V
Journal of Molecular Medicine, 87, 803-813 (2009)
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