SRP4166
IL-13 from rat
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonim(y):
ALRH, BHR1, IL-13, NC300, P600, interleukin 13
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About This Item
Polecane produkty
pochodzenie biologiczne
rat
rekombinowane
expressed in E. coli
Próba
≥95% (HPLC)
≥95% (SDS-PAGE)
Formularz
lyophilized
masa cząsteczkowa
~12.7 kDa
opakowanie
pkg of 10 μg
warunki przechowywania
avoid repeated freeze/thaw cycles
zanieczyszczenia
endotoxin, tested
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
rat ... Il13(116553)
Opis ogólny
IL13 (interleukin 13) is a classic cytokine produced by Th2 (T-helper) cells. It was originally identified as an inflammatory cytokine production-inhibiting T-cell derived cytokine. Recombinant rat IL-13 is an 11.9 kDa protein containing 109 amino acid residues.
Działania biochem./fizjol.
IL13 (interleukin 13) is up-regulated during parasitic infections, and participates in host′s protective immunity against Schistosoma japonicum. This protein promotes eosinophil activation resulting in elevated specific IgE against adult and larval antigens. During acute infection it promotes egg expulsion through increased intestinal contractility. It acts as a liver protective agent where it promotes formation of liver granulomas in a CD4+ T cell-mediated manner, which results in liver fibrosis. In airway disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis lung disease, IL13 promotes the formation of airway goblet cells, resulting in excess mucus secretion, which in turn, is regulated by IL13-activated autophagy.
Postać fizyczna
Sterile filtered and lyophilized with no additives.
Rekonstytucja
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can be diluted into other aqueous buffers.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
IL13 activates autophagy to regulate secretion in airway epithelial cells.
Dickinson JD, et.al.
Autophagy, 12, 397-409 (2016)
IL-13 effector functions
Wynn TA
Annual Review of Immunology, 21, 425-456 (2003)
Kihyuk Shin et al.
Clinical and experimental medicine, 15(3), 233-244 (2014-06-14)
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
Gui Yang et al.
The Journal of biological chemistry, 290(20), 12858-12867 (2015-04-04)
Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims
Xin Long et al.
PloS one, 10(8), e0135360-e0135360 (2015-08-11)
The aim of this study was to determine whether two polymorphisms in the gene encoding IL13 previously associated with Schistosoma hematobium (S. hematobium) and S. mansoni infection are associated with S. japonicum infection. Single nucleotide polymorphisms (SNPs) rs1800925 (IL13/-1112C>T) and
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