SRP3212
IL-5 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonim(y):
BCDFII, EDF, TRF
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.32
pochodzenie biologiczne
mouse
rekombinowane
expressed in E. coli
Próba
≥98% (HPLC)
≥98% (SDS-PAGE)
Postać
lyophilized
siła działania
≤2.0 ng/mL ED50
masa cząsteczkowa
26.2 kDa
opakowanie
pkg of 25 μg
metody
cell culture | mammalian: suitable
zanieczyszczenia
<0.1 EU/μg endotoxin, tested
kolor
white to off-white
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
mouse ... IL5(16191)
Opis ogólny
IL-5 (interleukin 5) is a Th2 (T helper 2) cytokine that is predominantly produced by T lymphocytes, and to a lower extent by mast cells, type 2 innate lymphoid (ILC2) cells, and eosinophils.
Recombinant murine IL-5 is a 26.2kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.
Recombinant murine IL-5 is a 26.2kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.
Działania biochem./fizjol.
IL-5 (interleukin 5) was initially identified as a stimulant of antibody production by activated B cells. It has recently been shown to be a key factor in eosinophil differentiation and proliferation. It is also implicated in the pathogenesis of asthma, atopy, hypereosinophilic syndromes, and parasitic infections. In distal lung, IL-5 recruits eosinophils and modulates inflammatory or immune cells in the microenvironment, thus, promoting lung metastasis in cancer.
Sekwencja
MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Postać fizyczna
Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
Rekonstytucja
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.
Zaynagetdinov R et al
Cancer Research, 75(8), 1624-1634 (2015)
Interleukin-5, eosinophils, and disease.
C J Sanderson
Blood, 79(12), 3101-3109 (1992-06-15)
H D Campbell et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(19), 6629-6633 (1987-10-01)
The human eosinophil differentiation factor (EDF) gene was cloned from a genomic library in lambda phage EMBL3A by using a murine EDF cDNA clone as a probe. The DNA sequence of a 3.2-kilobase BamHI fragment spanning the gene was determined.
Stefan Rebhandl et al.
European journal of immunology, 44(7), 2175-2187 (2014-03-29)
Activation-induced deaminase (AID) is a DNA-mutating enzyme that mediates class-switch recombination as well as somatic hypermutation of antibody genes in B cells. Due to off-target activity, AID is implicated in lymphoma development by introducing genome-wide DNA damage and initiating chromosomal
Yuan Wang et al.
Journal of immunology (Baltimore, Md. : 1950), 195(3), 1171-1181 (2015-06-28)
Complement is implicated in asthma pathogenesis, but its mechanism of action in this disease remains incompletely understood. In this study, we investigated the role of properdin (P), a positive alternative pathway complement regulator, in allergen-induced airway inflammation. Allergen challenge stimulated
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