SRP0186
Bcl-2 Active human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonim(y):
Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell leukemia/lymphoma 2
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About This Item
Kod UNSPSC:
12352200
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in E. coli
Próba
≥80% (SDS-PAGE)
Postać
aqueous solution
masa cząsteczkowa
27 kDa
opakowanie
pkg of 100 μg
warunki przechowywania
avoid repeated freeze/thaw cycles
stężenie
>0.02 mg/mL
numer dostępu NCBI
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... BCL2(596)
Opis ogólny
B-cell lymphoma 2 (BCL-2) is an anti-apoptotic and target gene of nuclear factor-κB (NF-κB). The protein is expressed in the nuclear envelope, mitochondria and endoplasmic reticulum. The gene encoding BCL-2 is localized on human chromosome 18q21. Human Bcl-2 (amino-acids 1-211) (GenBank Accession No. P10415) with C-terminal His tag, MW = 27 kDa, expressed in an E. coli expression system.
Zastosowanie
Useful for the study of apoptosis, screening inhibitors and selectivity profiling.
Działania biochem./fizjol.
B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas.
Postać fizyczna
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.
Uwaga dotycząca przygotowania
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Onursal Onen et al.
Sensors (Basel, Switzerland), 12(9), 12317-12328 (2012-11-01)
Changes in mass loading on the surface of acoustic biosensors result in output frequency shifts which provide precise measurements of analytes. Therefore, to detect a particular biomarker, the sensor delay path must be judiciously designed to maximize sensitivity and specificity.
Maria Lauda Tomasi et al.
Oncotarget, 6(35), 37706-37723 (2015-09-30)
Ubiquitin-conjugating enzyme 9 (Ubc9) is required for sumoylation and inhibits apoptosis via Bcl-2 by unknown mechanism. Methionine adenosyltransferase 2A (MAT2A) encodes for MATα2, the catalytic subunit of the MATII isoenzyme that synthesizes S-adenosylmethionine (SAMe). Ubc9, Bcl-2 and MAT2A expression are
Rr Suzy Indharty
Asian journal of neurosurgery, 8(2), 83-89 (2013-09-21)
Traumatic brain injury (TBI) is one of the major causes of death and disability. Apoptosis after TBI contributes significantly to the final extent of tissue damage. The Bcl-2 family proteins are important apoptosis modulators which increased in injured neurons. Bcl-2
Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells.
Christelle Villeneuve et al.
Molecular biology of the cell, 22(7), 999-1013 (2011-02-04)
Although the anti-apoptotic activity of Bcl-2 has been extensively studied, its mode of action remains incompletely understood. Deciphering the network of Bcl-2 interacting factors is necessary to better understand the key function of Bcl-2 in apoptosis initiation. To identify novel
P. Riederer
Advances in Research on Neurodegeneration, 5 null
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