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SML0346

Sigma-Aldrich

Alosetron hydrochloride

≥98% (HPLC)

Synonim(y):

2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride

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About This Item

Wzór empiryczny (zapis Hilla):
C17H18N4O·HCl
Numer CAS:
122852-69-1
Masa cząsteczkowa:
330.81
Numer MDL:
MFCD09028027
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329825350
NACRES:
NA.77

Poziom jakości

100

Próba

≥98% (HPLC)

Postać

powder

warunki przechowywania

desiccated

kolor

white to beige

rozpuszczalność

H2O: ≥5 mg/mL at warmed

temp. przechowywania

2-8°C

ciąg SMILES

CN1C2=C(C=CC=C2)C3=C1CCN(CC4=C(C)N=CN4)C3=O.Cl

InChI

1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H

Klucz InChI

FNYQZOVOVDSGJH-UHFFFAOYSA-N

informacje o genach

human ... HTR3A(3359)

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Działania biochem./fizjol.

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.
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Piktogramy

Skull and crossbones
GHS06

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H301 - H319 - H412

Zwroty wskazujące środki ostrożności

P273 - P301 + P310 + P330 - P305 + P351 + P338

Klasyfikacja zagrożeń

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2

Kod klasy składowania

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Roja Rahimi et al.
Clinical therapeutics, 30(5), 884-901 (2008-06-17)
Stimulated 5-hydroxytryptamine-3 (5-HT(3)) receptors promote intestinal motility, secretion, and sensation, effects that are related to the known pathophysiology of irritable bowel syndrome (IBS). A previous meta-analysis of 6 randomized controlled trials of the 5-HT(3)-receptor antagonist alosetron found that this agent
J M Jarcho et al.
Alimentary pharmacology & therapeutics, 28(3), 344-352 (2008-12-17)
Symptom improvement in irritable bowel syndrome (IBS) treatment trials varies widely, with only 50-70% of patients qualifying as responders. Factors predicting treatment responsiveness are not known, although we have demonstrated that symptom improvement with the 5-HT3R antagonist alosetron is correlated
Jean Paul Nicandro et al.
Current medical research and opinion, 28(3), 449-456 (2012-02-09)
This article evaluates the characteristics and treatment patterns of female patients with severe diarrhea-predominant irritable bowel syndrome (IBS-D) who were treated with alosetron under a risk management program. Patients prescribed alosetron (2002-2009) and who voluntarily enrolled in the follow-up study
Eric Shah et al.
The American journal of medicine, 125(4), 381-393 (2012-03-27)
Current treatment options for irritable bowel syndrome are limited and often poorly studied. A select few drugs have been studied in irritable bowel syndrome, and the number needed to treat is frequently used to assess the relative efficacy of these
Lin Chang et al.
The American journal of gastroenterology, 105(4), 866-875 (2010-03-04)
Alosetron is a potent, selective 5-HT(3) receptor antagonist prescribed for women with severe diarrhea-predominant irritable bowel syndrome (IBS-D) under a risk management plan (RMP). The RMP was implemented following cases of ischemic colitis (IC) and complications of constipation (CoC) associated
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