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SML0202

Sigma-Aldrich

DPH

≥98% (HPLC)

Synonim(y):

5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione

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About This Item

Wzór empiryczny (zapis Hilla):
C18H13FN4O2
Numer CAS:
484049-04-9
Masa cząsteczkowa:
336.32
Numer MDL:
MFCD03268950
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329825226
NACRES:
NA.77

Poziom jakości

100

Próba

≥98% (HPLC)

Postać

powder

kolor

white to tan

rozpuszczalność

DMSO: ≥10 mg/mL

temp. przechowywania

2-8°C

ciąg SMILES

Fc1ccc(cc1)-c2nn(cc2C3NC(=O)NC3=O)-c4ccccc4

InChI

1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25)

Klucz InChI

MPQWYPLPWGUMJE-UHFFFAOYSA-N

Zastosowanie

DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies.

Działania biochem./fizjol.

DPH binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase. It exhibits potent enzymatic and cellular activity that stimulates the activation of c-Abl.
DPH is a potent cell permeable c-Abl activator. DPH binds to the myristoyl binding site and leads to activation of c-Abl kinase activity. The compound stimulates the phosphorylation of c-Abl and its downstream substrate Crk.

Cechy i korzyści

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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