SML0101

Montelukast sodium hydrate

≥98% (HPLC)

• Synonim(y): 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate
• Wzór empiryczny (zapis Hilla): C₃₅H₃₅ClNO₃S·Na · xH₂O
• Masa cząsteczkowa: 608.17 (anhydrous basis)
• Numer MDL: MFCD20527317
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825159
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: powder
• aktywność optyczna: [α]/D +90 to +106° in methanol (c=1)
• warunki przechowywania: desiccated
• kolor: white to tan
• rozpuszczalność: DMSO: ≥8 mg/mL at 60 °C
• inicjator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temp. przechowywania: 2-8°C
• ciąg SMILES: O.[Na+].CC(C)(O)c1ccccc1CC[C@@H](SCC2(CC2)CC([O-])=O)c3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3
• InChI: 1S/C35H36ClNO3S.Na.H2O/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);;1H2/q;+1;/p-1/b15-10+;;/t32-;;/m1../s1
• Klucz InChI: QAXHQHBRRJHZHL-ZPQUALOVSA-M

Opis

Zastosowanie

Montelukast sodium hydrate has been used as a positive control drug to study the protective effects of Gumiganghwal-tang aqueous extract (GGTA) against airway inflammation and pulmonary fibrosis.

Działania biochem./fizjol.

Montelukast sodium hydrate is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is a subtype specific CysLT1 receptor antagonist.

Montelukast sodium hydrate is subtype specific CysLT1 receptor antagonist; Antiasthmatic; antiallergic

Cechy i korzyści

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable