SAB4503329
Anti-DARPP-32 antibody produced in rabbit
affinity isolated antibody
Synonim(y):
Dopamine- and cAMP-regulated neuronal phosphoprotein, IPPD, Neuronal phosphoprotein DARPP-32, PPP1R1B
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About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 22 kDa
reaktywność gatunkowa
mouse, rat, human
stężenie
~1 mg/mL
metody
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... PPP1R1B(84152)
Opis ogólny
Anti-DARPP-32 Antibody detects endogenous levels of total DARPP-32 protein.
PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B)/DARPP32 (dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa) encodes two transcripts which are further translated into two DARPP-32 protein isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. It is located on human chromosome 17q12.
The DARPP-32 (dopamine and cAMP-regulated neuronal phosphoprotein 2) gene is mapped to human chromosome 17q12. The gene is expressed predominantly in spiny neurons of the neostriatum and specifically localized in caudate, putamen, nucleus accumbens, cerebral and cerebellar cortex. The gene encodes two isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. The lack of the first 36 residues at the N-terminal in t- DARPP marks the difference between the two isoforms. Anti-DARPP-32 Antibody detects endogenous levels of total DARPP-32 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human DARPP-32.
Immunogen Range: 41-90
Immunogen Range: 41-90
Działania biochem./fizjol.
DARPP-32 (dopamine and cAMP-regulated neuronal phosphoprotein 2) is a dopaminergic gene that influences dopamine receptor binding potential in the corpus striatum. The gene also regulates the availability of dopamine neurotransmitter, which is important for cognitive capacities. Therefore, variation in this gene affects category learning performance. (t)-DARPP takes part in the process of tumorigenesis by stimulating chemokine receptor 4 and also promoting cell proliferation. Elevated expression of the DARPP-32 gene in dorsolateral prefrontal neocortex and hippocampus is correlated with the development of schizophrenia and cognitive disorders. The encoded protein is a phosphorylation-dependent inhibitor. DARPP-32 is associated with the pathogenesis of gastric cancer and breast cancer with its anti-apoptotic property, and is found to promote angiogenesis.
PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B)/DARPP32 (dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa) is considered as an inhibitor of phosphate-1 (PP-1) protein. It is associated with working memory and emotion processing.
Cechy i korzyści
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Postać fizyczna
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Dopaminergic genetic polymorphisms predict rule-based category learning.
Byrne K A, et al.
Journal of Cognitive Neuroscience, 28(7), 959-970 (2016)
Jay V Deng et al.
Neuroscience, 369, 212-221 (2017-11-21)
Many neuropsychiatric disorders are associated with abnormal decision making involving risk of punishment, but the underlying molecular basis remains poorly understood. Methyl CpG-binding protein 2 (MeCP2) is an epigenetic factor that regulates transcription by directly binding to methylated DNA. Here
Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis.
Chen Z, et al.
Gut (2015)
Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas.
Belkhiri A, et al.
Cancer Research, 65(15), 6583-6592 (2005)
Human t-DARPP is induced during striatal development.
Straccia M, et al.
Neuroscience, 333, 320-330 (2016)
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