SAB4502262
Anti-PPAR-γ antibody produced in rabbit
affinity isolated antibody
Synonim(y):
NR1C3, PPAR-γ-1, Peroxisome proliferator activated receptor γ
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About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 57 kDa
reaktywność gatunkowa
mouse, rat, human
stężenie
~1 mg/mL
metody
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... PPARG(5468)
Powiązane kategorie
Opis ogólny
Peroxisome proliferator-activated receptor γ (PPARγ) is one of the subtypes of PPAR, and belongs to the nuclear hormone receptor superfamily. PPARγ is further sub classified into four isoforms and they have tissue specific expression. PPARγ is encoded by the gene mapped to human chromosome 3p25. PPARγ contains N- terminal AF (activation function)-1 transactivation domain, followed by a DNA-binding domain and a dimerization and ligand-binding domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human PPAR-gamma.
Immunogen Range: 78-127
Immunogen Range: 78-127
Działania biochem./fizjol.
Peroxisome proliferator-activated receptor γ (PPARγ) induces the expression of genes coding for proteins implicated in glucose and lipid metabolism. Natural PPAR-γ agonists found in foods functions as an anti-inflammatory molecule, thus, PPARγ is not only a target of the pharmaceutical industry, but also a novel target of the food industry. PPAR-γ regulates energy storage, adipocyte differentiation, and cellular inflammatory and ischemic responses. PPARγ is also involved in the production of prostanoids that regulate vascular function. PPARγ agonists, thiazolidinediones including rosiglitazone and pioglitazone, enhance insulin sensitivity by inhibiting the tumor necrosis factor α (TNF-α) activity in adipocytes. These PPAR-γ agonists are used in the treatment of type 2 diabetes. PPARγ functions as a potential therapeutic target in pulmonary hypertension.
Cechy i korzyści
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Postać fizyczna
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases.
Tyagi S
Journal of Advanced Pharmaceutical Technology & Research, 2(4), 236-240 (2011)
PPARgamma as a potential therapeutic target in pulmonary hypertension.
Sutliff RL
Therapeutic Advances in Respiratory Disease, 4(3), 143-160 (2010)
Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock.
Abdelrahman M
Cardiovascular Research, 65(4), 772-781 (2005)
Mariami Jasaszwili et al.
Molecular and cellular endocrinology, 496, 110532-110532 (2019-08-11)
Adropin is a protein encoded by Energy Homeostasis Associated (Enho) gene which is expressed mainly in the liver and brain. There is evidence that biological effects of adropin are mediated via GPR19 activation. Animal studies showed that adropin modulates adiposity
Anna Salazar-Degracia et al.
Biochimie, 149, 79-91 (2018-04-15)
Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Beta-adrenoceptors attenuate muscle wasting. We hypothesized that specific muscle atrophy signaling pathways and altered metabolism may be attenuated in cancer cachectic animals receiving treatment with
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