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SAB4300100

Sigma-Aldrich

Anti-phospho-ATM (pSer1981) antibody produced in rabbit

affinity isolated antibody

Synonim(y):

Anti-AT1 antibody produced in rabbit, Anti-ATA antibody produced in rabbit, Anti-ATC antibody produced in rabbit, Anti-ATD antibody produced in rabbit, Anti-ataxia telangiectasia mutated antibody produced in rabbit

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About This Item

Numer MDL:
Kod UNSPSC:
12352203
NACRES:
NA.41
białko sprzężone:
unconjugated
application:
IHC (p)
klon:
polyclonal
reaktywność gatunkowa:
human
citations:
29
metody:
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

pochodzenie biologiczne

rabbit

Poziom jakości

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Formularz

buffered aqueous solution

masa cząsteczkowa

~350 kDa

reaktywność gatunkowa

human

stężenie

1 mg/mL

metody

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

izotyp

IgG

sekwencja immunogenna

(E-G-SP-Q-S)

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

phosphorylation (pSer1981)

informacje o genach

human ... ATM(472)

Immunogen

Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S), according to the protein ATM.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Opis wartości docelowych

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cyclecheckpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNArepair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cellcycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcriptvariants encoding different isoforms have been found for this gene.

Postać fizyczna

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Certyfikaty analizy (CoA)

Lot/Batch Number

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Yajie Wang et al.
Scientific reports, 7(1), 9989-9989 (2017-09-01)
A novel podophyllotoxin derivative, XWL-1-48, was synthesized as an oral topoisomerase II inhibitor. kDNA decatenation assay indicated that XWL-1-48 significantly inhibited topoisomerase II activity in a concentration-dependent manner. Moreover, the cytotoxicity of XWL-1-48 is more potent than its congener GL331
Manal A Farg et al.
Human molecular genetics, 26(15), 2882-2896 (2017-05-10)
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease affecting motor neurons. Hexanucleotide (GGGGCC) repeat expansions in a non-coding region of C9orf72 are the major cause of familial ALS and frontotemporal dementia (FTD) worldwide. The C9orf72 repeat expansion undergoes
Zujun Que et al.
BMC complementary and alternative medicine, 19(1), 204-204 (2019-08-09)
Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been clinically available for the treatment of non-small cell lung
Pinakin Pandya et al.
Cellular signalling, 62, 109340-109340 (2019-06-09)
Protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3 (Glrx3)) is a ubiquitously expressed protein that possesses an N-terminal monothiol thioredoxin (Trx) domain and two C-terminal tandem copies of a monothiol Glrx domain. It has an overall
Moshe Giladi et al.
Radiation oncology (London, England), 12(1), 206-206 (2017-12-30)
Tumor Treating Fields (TTFields) are an anti-neoplastic treatment modality delivered via application of alternating electric fields using insulated transducer arrays placed directly on the skin in the region surrounding the tumor. A Phase 3 clinical trial has demonstrated the effectiveness

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