SAB1400494

Anti-ANKRD1 antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

• Synonim(y): Anti-ALRP, Anti-C-193, Anti-CARP, Anti-CVARP, Anti-MCARP, Anti-bA320F15.2
• Numer MDL: MFCD00164711
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• białko sprzężone: unconjugated
• forma przeciwciała: IgG fraction of antiserum
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• reaktywność gatunkowa: human
• metody: indirect immunofluorescence: suitable; western blot: 1 μg/mL
• numer dostępu UniProt: Q15327
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... ANKRD1(27063)

Opis

Opis ogólny

Ankyrin repeat domain-containing protein 1 (ANKRD1) is a member of muscle ankyrin repeat protein. It comprises a nuclear localization signal, four repeats of an ankyrin motif, and a PEST-like sequence. The ANKRD1 gene is mapped to human chromosome 10q23.31. It is expressed in skeletal and cardiac muscles.

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. (provided by RefSeq)

Immunogen

ANKRD1 (NP_055206.2, 1 a.a. ~ 319 a.a) full-length human protein.

Sequence
MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF

Działania biochem./fizjol.

Ankyrin repeat domain-containing protein 1 (ANKRD1) acts as a transcriptional regulator for cardiomyogenesis. It interacts with calsequestrin-2, intermediate filament protein desmin, and with Y-box transcription factor 1 (YB-1). Elevated expression of ANKRD1 is implicated in idiopathic dilated cardiomyopathy. The hepatitis C virus (HCV) coordinates with ANKRD1 for its entry and propagation. It serves as a co-activator of the p53 tumor suppressor protein and may regulate apoptosis in human ovarian cancer cells.

Postać fizyczna

Solution in phosphate buffered saline, pH 7.4

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable