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Key Documents
S9072
Anti-SOX2 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonim(y):
Anti-Sex-determining region Y-box 2
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About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 34-37 kDa
reaktywność gatunkowa
human, rat, mouse
stężenie
~1 mg/mL
metody
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... SOX2(6657)
mouse ... Sox2(20674)
rat ... Sox2(499593)
Opis ogólny
Transcription factor SOX-2 (SOX-2) is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. When SOX-2 is expressed in self renewing progenitor cells, it acts to inhibit neuronal differentiation. Conversely, active repression of SOX-2 induces neural differentiation.
Specyficzność
Rabbit polyclonal anti-SOX2 antibody recognizes human, mouse, rat sex-determining region Y-box 2 transcription factors.
Immunogen
synthetic peptide corresponding to residues 32-47 of human SOX2.
Zastosowanie
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Rabbit polyclonal anti-SOX2 antibody is used to tag solute sex-determining region Y-box 2 transcription factor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques, such as immunoblotting (~37 kDa) and flow cytometry. It is used as a probe to determine the presence and roles of sex-determining region Y-box 2 transcription factor in progenitor cell self renewal and differentiation.
Postać fizyczna
solution in phosphate buffered saline, containing 0.02% sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Bartolo Bono et al.
Scientific reports, 8(1), 13838-13838 (2018-09-16)
Cancer stem cells (CSCs) have been involved in the maintenance, progression and relapse of several tumors, but their origin is still elusive. Here, in vitro transformed human fibroblasts (cen3tel cells) and the tumorsphere assay were used to search for and
Elisa Latorre et al.
Molecular pharmacology, 89(2), 243-252 (2015-12-18)
Since 2005, sex determining region y-box 2 (SOX2) has drawn the attention of the scientific community for being one of the key transcription factors responsible for pluripotency induction in somatic stem cells. Our research investigated the turnover regulation of SOX2
Dasa Dolezalova et al.
Stem cells (Dayton, Ohio), 30(7), 1362-1372 (2012-04-19)
Studies of human embryonic stem cells (hESCs) commonly describe the nonfunctional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly present and upregulated after
Martyna Łupicka et al.
Reproduction (Cambridge, England), 149(4), 317-327 (2015-01-04)
The aim of this study was to identify uterine pluripotent cells both in bovine uterine tissues as well in epithelial, stromal, and myometrial uterine cell populations. Moreover, the relationship of pluripotent markers expression with age and the uterine horn side
Jizhen Lin et al.
American journal of physiology. Cell physiology, 296(3), C441-C452 (2009-03-06)
Multipotent cochlear neural progenitors (CNPs) in the organ of Corti hold the promise for cell replacement in degenerative hearing disorders. However, not much is known about the CNPs and the specific conditions for their differentiation. Here we isolate the CNPs
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