S6201

Salinomycin, Ready Made Solution

from Streptomyces albus, ≥98% (HPLC)

• Synonim(y): Antibiotic 61477, Coxxistac
• Wzór empiryczny (zapis Hilla): C₄₂H₇₀O₁₁
• Masa cząsteczkowa: 751.00
• Numer MDL: MFCD25541652
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329824560
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: Streptomyces albus
• Poziom jakości: 200
• Próba: ≥98% (HPLC)
• stężenie: 2 mg/ml
• rozpuszczalność: DMSO: soluble; H₂O: insoluble; alcohols: soluble; carbon tetrachloride: soluble; chloroform: soluble; ethers and esters: soluble; hexane: soluble
• spektrum działania antybiotyku: neoplastics
• Tryb działania: cell membrane | interferes
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: C[C@@H]1O[C@]([C@]2(C)CC[C@]3([C@H](O)C=C[C@]4(O[C@@]([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@@]5([H])[C@@H](C)CC[C@@]([C@H](C(O)=O)CC)([H])O5)=O)([H])[C@@H](C)C[C@H]4C)O3)O2)([H])CC[C@]1(O)CC
• InChI: 1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
• Klucz InChI: KQXDHUJYNAXLNZ-XQSDOZFQSA-N

Opis

Opis ogólny

Chemical structure: polyether

Zastosowanie

Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells. It has also been used in sequential treatment of cancer cells to study resistance.

Działania biochem./fizjol.

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K⁺ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K⁺ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

Postać fizyczna

The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 188.6 °F - closed cup
• Temperatura zapłonu (°C): 87 °C - closed cup