Przejdź do zawartości
Merck
Wszystkie zdjęcia(1)

Key Documents

View All Documentation

S5637

Sigma-Aldrich

Sulfamethazine sodium salt

≥98%

Synonim(y):

4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(1)

About This Item

Wzór liniowy:
C12H13N4O2SNa
Numer CAS:
1981-58-4
Masa cząsteczkowa:
300.31
Numer WE:
217-840-0
Numer MDL:
MFCD00068333
Kod UNSPSC:
51284910
Identyfikator substancji w PubChem:
24899666
NACRES:
NA.85

Poziom jakości

200

Próba

≥98%

Postać

powder

warunki przechowywania

(Keep container tightly closed in a dry and well-ventilated place.)

kolor

white to off-white

rozpuszczalność

H2O: soluble 50 mg/mL

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria

Tryb działania

DNA synthesis | interferes
enzyme | inhibits

temp. przechowywania

2-8°C

ciąg SMILES

[Na].Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;

Klucz InChI

WIVZAHIZHZEEOX-UHFFFAOYSA-N

Opis ogólny

Chemical structure: sulfonamide

Zastosowanie

Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine.

Działania biochem./fizjol.

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

Opakowanie

25G,100G

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.
This page may contain text that has been machine translated.

Piktogramy

Exclamation mark
GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H302

Zwroty wskazujące środki ostrożności

P264 - P270 - P301 + P312 - P501

Klasyfikacja zagrożeń

Acute Tox. 4 Oral

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Klienci oglądali również te produkty

Slide 1 of 5

1 of 5

Norfloxacin VETRANAL®, analytical standard

Supelco

33899

Norfloxacin

Sulfamerazine ReagentPlus®, ≥99.0%

Sigma-Aldrich

S8876

Sulfamerazine

Sulfadiazine 99.0-101.0%

Sigma-Aldrich

S8626

Sulfadiazine

Acriflavine hydrochloride fluorescent dye

Sigma-Aldrich

A8251

Acriflavine hydrochloride

Ceftazidime hydrate 90.0-105.0%, contains ~10% sodium carbonate as stabilizer

Sigma-Aldrich

C3809

Ceftazidime hydrate

C J Chapron et al.
Journal of clinical pharmacology, 16(7), 338-344 (1976-07-01)
The relationship between sulfamethazine disposition kinetics and acetylation phenotype was studied in man. Sulfamethazine pharmacokinetic parameters were determined after the administration of the drug as an oral suspension. When the half-life, acetylation rate constant, or per cent available dose excreted
Tangbin Yang et al.
Hybridoma (2005), 29(5), 403-407 (2010-11-06)
A specific monoclonal antibody (MAb) against sulfamethazine was produced with hybridoma technology. This assay shows very high sensitivity with IC50 of 0.4 ng/mL and LOD of 0.05 ng/mL when it was run in 0.02 mol/L PBS (pH 7.5). This MAb has shown high
A D Mitchell et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 161-165 (1986-03-01)
Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). The animals were sacrificed at 8 hr or 2, 5, or 10 days after the last dose was given and tissues
Craig Knox et al.
Nucleic acids research, 39(Database issue), D1035-D1041 (2010-11-10)
DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism and pharmaceutical properties of both small molecule and large molecule (biotech) drugs.
Thomas H Miller et al.
The Science of the total environment, 511, 153-160 (2014-12-30)
The development, characterisation and application of a new analytical method for multi-residue PPCP determination in the freshwater amphipod, Gammarus pulex are presented. Analysis was performed using pulverised liquid extraction (PuLE), solid phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej