S2947

Anti-Synapsin II (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonim(y): Anti-SYN2, Anti-SYNII, Anti-SYNIIa, Anti-SYNIIb, Anti-Synapsin 2
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: antigen ~74 kDa (synapsin IIa)
• reaktywność gatunkowa: human, mouse, rat
• opakowanie: antibody small pack of 25 μL
• rozszerzona walidacja: recombinant expression; Learn more about Antibody Enhanced Validation
• stężenie: ~1.5 mg/mL
• metody: western blot: 0.25-0/5 μg/mL using extracts of HEK-293T cells expressing human synapsin II, mouse brain extract (S1 fraction), and rat PC12 cell lysate
• numer dostępu UniProt: Q92777
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... SYN2(6854) ; mouse ... Syn2(20965) ; rat ... Syn2(29179)

Opis

Opis ogólny

Synapsins are a family of neuron-specific phosphoproteins that are localized on the cytoplasmic surface of small synaptic vesicles. Synapsins are ubiquitously expressed in neurons. The synapsin 2 (Syn2) gene is located on human chromosome 3p25. It belongs to the neuronal phosphoprotein family.

Specyficzność

Anti-Synapsin II(C-terminal) specifically recognizes human, rat and mousesynapsin II.

Immunogen

synthetic peptide corresponding to amino acids 569-586 of rat synapsin IIa isoform, conjugated to KLH. This sequence is identical in rat synapsin IIa, human synapsin IIa, and mouse synapsin II, and is not found in rat and human synapsin IIb.

Zastosowanie

Anti-Synapsin II (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Działania biochem./fizjol.

Synapsins regulate synaptic vesicle clustering and the formation of synaptic terminals. Synapsin II (Syn2) is involved in the formation of synaptic terminals during neuronal development. It can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. It is proposed as a candidate associated with increased vulnerability to schizophrenia. It plays an important role in synaptogenesis and neurotransmitter release. Syn2 also helps to locate nitric oxide synthase to the vicinity of its targets.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Przechowywanie i stabilność

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slightturbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)