P9129

5-Pregnen-3β-ol-20-one

≥98%

• Synonim(y): 3β-Hydroxy-5-pregnen-20-one, Pregnenolone
• Wzór empiryczny (zapis Hilla): C₂₁H₃₂O₂
• Numer CAS: 145-13-1
• Masa cząsteczkowa: 316.48
• Beilstein: 2059026
• Numer WE: 205-647-4
• Numer MDL: MFCD00003628
• Kod UNSPSC: 12352211
• Identyfikator substancji w PubChem: 24899008
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Poziom jakości: 200
• Próba: ≥98%
• Formularz: powder
• rozpuszczalność: ethanol: soluble 10 mg/mL, clear, colorless to faintly yellow
• grupa funkcyjna: ketone
• Warunki transportu: ambient
• temp. przechowywania: room temp
• ciąg SMILES: [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
• InChI: 1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
• Klucz InChI: ORNBQBCIOKFOEO-QGVNFLHTSA-N
• informacje o genach: human ... SERPINA6(866) ; rat ... Ar(24208)

Opis

Zastosowanie

5-Pregnen-3β-ol-20-one is suitable for use:

• as a substrate for 3β-HSD at a concentration of 1 μg/mL to study the time-dependent effect of reduced oxygen tension on 3β-hydroxysteroid dehydrogenase (3β-HSD) activity
• as a progestin precursor to study the effects of splenic macrophages on progestin secretion of luteal cells
• in the testicular interstitial cell culture medium at a concentration of 15mg/mL

Działania biochem./fizjol.

One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.

Testosterone production in rats occurs in Leydig cells of the testis via the Δ⁴ pathway. Cholesterol is first converted to pregnenolone, then to progesterone, and finally to testosterone. Pregnenolone is the key neurosteroid synthesized in steroidogenic glands. It is also present as a sulfate ester that serves as an antagonist of GABAergic neurons by interacting with γ-aminobutyric acid (GABA) receptor.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)