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Key Documents
P9114
6-(2-Propargyloxyphenyl)hexanoic acid
≥98%, solid
Synonim(y):
PPOH
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About This Item
Wzór empiryczny (zapis Hilla):
C15H18O3
Numer CAS:
Masa cząsteczkowa:
246.30
Numer MDL:
Kod UNSPSC:
12352106
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
pochodzenie biologiczne
synthetic
Poziom jakości
Próba
≥98%
Postać
solid
Warunki transportu
wet ice
temp. przechowywania
−20°C
ciąg SMILES
OC(=O)CCCCCc1ccccc1OCC#C
InChI
1S/C15H18O3/c1-2-12-18-14-10-7-6-9-13(14)8-4-3-5-11-15(16)17/h1,6-7,9-10H,3-5,8,11-12H2,(H,16,17)
Klucz InChI
CUNYTKVXYZYERK-UHFFFAOYSA-N
Opis ogólny
PPOH is a synthetic, acetylenic fatty acid and a selective inhibitor of arachidonate epoxygenation reactions catalyzed by certain microsomal cytochrome P450 (CYP) enzymes. PPOH inhibits the reaction of epoxide formation (IC50 of 90 μM) at arachidonate positions 11 and 12 by CYP4A2 and CYP4A3 isozymes. PPOH does not inhibit the ω-hydroxylation reaction of CYP4A1 leading to the formation of 20-HETE.1 Arachidonate metabolism studies using inhibitors such as PPOH may be useful in elucidating the role of metabolites in regulating renal function and hypertension.
Działania biochem./fizjol.
Selective inhibitor of epoxygenation catalyzed by CYP450 isozymes.
Uwaga dotycząca przygotowania
PPOH is soluble in the following organic solvents:ethanol, DMSO, and N,N-dimethylformamide (DMF). It is at least soluble to 50 mg/ml in each solvent. The organic solvents should first be purged with an inert gas such as argon before preparation of the stock solutions to minimize any possible oxidation of the unsaturated PPOH. Stock solutions will be stable for at least one year as aliquots stored at –20 °C and under a layer of argon or dry nitrogen. The stock solution should be further diluted into aqueous buffers or isotonic saline (ensure that the residual amount of organic solvent is not causing physiological effects at low concentrations of the organic solvent) for biological experiments. Alternatively, if an organic solvent-free aqueous solution is desired, directly dissolve the crystalline PPOH in aqueous buffers. The solubility of PPOH is at least 0.5 mg/ml in PBS buffer, pH 7.2. Do not store aqueous solutions for more than one day.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
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Prostaglandins & other lipid mediators, 131, 17-24 (2017-05-06)
Hyperdynamic circulation contributes to the progress of portal hypertension in liver cirrhosis. We investigated the effects of soluble epoxide hydrolase (sEH) inhibition on portal pressure and the myogenic response of mesenteric arteries isolated from cirrhotic rats using the sEH inhibitor
Wen-ting You et al.
Acta pharmacologica Sinica, 37(3), 368-381 (2016-02-04)
CYP2J3 in myocardium metabolizes arachidonic acid to 4 regioisomeric epoxyeicosatrienoic acids (EETs), which have diverse biological activities in rat heart. In this study we examined whether CYP2J3 was involved in cardioprotective effects of ophiopogonin D (OPD), a steroidal glycoside isolated
Jie Zhang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 109, 1498-1505 (2018-12-16)
Cardiac hypertrophy is a key pathological process in the context of diabetic cardiomyopathy. Naringenin exhibits multiple pharmacological activities, but the effect of naringenin on cardiomyocyte hypertrophy under diabetic conditions is still far from clear. Cardiomyocyte hypertrophy was induced by high
V Lamounier-Zepter et al.
International journal of obesity (2005), 39(5), 755-761 (2014-11-06)
Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-chain fatty acids and eicosanoids. Recent evidence has supported a novel
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