P7443

L-α-Phosphatidylcholine

from soybean, ≥99% (TLC), lyophilized powder

• Synonim(y): 1,2-Diacyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, L-α-Lecithin, Azolectin, PC
• Numer CAS: 8002-43-5
• Beilstein: 5209585
• Numer WE: 232-307-2
• Kod UNSPSC: 12352211
• NACRES: NA.25

Właściwości

• pochodzenie biologiczne: soybean
• Poziom jakości: 200
• Próba: ≥99% (TLC)
• Formularz: lyophilized powder
• grupa funkcyjna: phospholipid
• typ lipidu: phosphoglycerides
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• ciąg SMILES: [P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
• Klucz InChI: JLPULHDHAOZNQI-ZTIMHPMXSA-N

Opis

Opis ogólny

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk. It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes. It is essential for the acetylcholine synthesis functions to nourish the brain. PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD). It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease. PC administration therapy is effective for treating benign symmetric lipomatosis.

Zastosowanie

L-α-Phosphatidylcholine has been used:

• for liposome preparation
• as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)
• as a component of serum free substitute for whole blood cells

Działania biochem./fizjol.

A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter.

Opakowanie

Packaged under Argon

Uwaga dotycząca przygotowania

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)