P5208
Platelet-Derived Endothelial Cell Growth Factor human
≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
Synonim(y):
PD-ECGF
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Polecane produkty
Nazwa produktu
Platelet-Derived Endothelial Cell Growth Factor human, recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
pochodzenie biologiczne
human
Poziom jakości
rekombinowane
expressed in baculovirus infected Sf21 cells
Próba
≥97% (SDS-PAGE)
Formularz
lyophilized powder
siła działania
5-30 ng/mL EC50
masa cząsteczkowa
49 kDa
opakowanie
pkg of 10 μg
warunki przechowywania
avoid repeated freeze/thaw cycles
metody
cell culture | mammalian: suitable
zanieczyszczenia
<1 EU/mg
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... PDGFA(100126841) , TYMP(1890)
Opis ogólny
Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) is an endothelial cell mitogen which was originally purified from human platelets. In contrast with the endothelial mitogens of the fibroblast growth factor (FGF) family, PD-ECGF is an endothelial cell growth factor initially purified from human platelets, which does not bind to heparin and does not stimulate the proliferation of fibroblasts. This is in contrast with the effect of PDGF, which stimulates the growth of human foreskin fibroblasts, but is inactive on endothelial cells. PD-ECGF will stimulate endothelial cells in vitro and in vivo. PD-ECGF is chemotactic for bovine aortic endothelial cells. PD-ECGF does not induce smooth muscle cell migration. PD-ECGF is involved in angiogenesis and has potent angiogenic activity both in the developing vascular system of the chick chorioallantoic membrane and in vascularization of tumors in nude mice. PD-ECGF has a pI of 4.0-4.8 and a molecular weight of 49 kDa.
The biological activity of recombinant, human PD-ECGF is measured in a cell proliferation assay using human umbilical vein endothelial cells. The EC50 is defined as the effective concentration of growth factor that elicits a 50% increase in cell growth in a cell based bioassay
The biological activity of recombinant, human PD-ECGF is measured in a cell proliferation assay using human umbilical vein endothelial cells. The EC50 is defined as the effective concentration of growth factor that elicits a 50% increase in cell growth in a cell based bioassay
Zastosowanie
PD-ECGF jest zaangażowany w angiogenezę i ma silną aktywność angiogenną zarówno w rozwijającym się układzie naczyniowym błony kosmówkowo-alantoicznej kurcząt, jak i w unaczynieniu guzów u nagich myszy.
Działania biochem./fizjol.
Platelet-derived endothelial cell growth factor is a 45 kDa endothelial cell mitogen of pI 4.0-4.8 originally purified from human platelets. PD-ECGF is chemotactic for bovine aortic endothelial cells, however it does not induce smooth muscle cell migration. PD-ECGF is involved in angiogenesis and has potent angiogenic activity both in the developing vascular system of the chick chorioalantoic membrane and vascularization of tumor cells in nude mice. PD-ECGF is highly expressed in some tumors.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Komentarz do analizy
The proliferative activity of human PD-ECGF is measured in culture by using human umbilical vein endothelial cells.
Ta strona może zawierać tekst przetłumaczony maszynowo.
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Wybierz jedną z najnowszych wersji:
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
H Aikawa et al.
Anticancer research, 19(5B), 4305-4309 (2000-01-11)
In order to elucidate the roles of tumor angiogenesis in lung carcinogenesis, the expressions of several angiogenic factors in lung carcinoma tissues were examined. Tissue specimens from 112 cases of resected non-small cell lung cancer (NSCLC) were studied. The expressions
Jue Li et al.
Bioengineered, 13(3), 4844-4856 (2022-02-15)
The association between spinal cord injury (SCI) and bladder symptoms has been intensively described. Human umbilical cord mesenchymal stem cell (hUC-MSC) treatment is beneficial to the recovery of bladder function after SCI, but its mechanism is unclear. We established an
L Griffiths et al.
British journal of cancer, 76(6), 689-693 (1997-01-01)
Angiogenesis plays an important role in the growth and metastasis of solid tumours. Platelet-derived endothelial cell growth factor (PD-ECGF) is known to be chemotactic for endothelial cells in vitro and angiogenic in vivo. It is also known as gliostatin, a
C-S Bao et al.
European review for medical and pharmacological sciences, 22(19), 6436-6447 (2018-10-20)
This research aimed to investigate the therapeutic effects of transplanted human umbilical cord mesenchymal stem cells (hUCMSCs) on spinal cord injury in mice and to explore its molecular mechanism. Spinal cord injury model in C57BL/6J mice was established. On the
Sinsuk Han et al.
Autophagy, 17(12), 4182-4201 (2021-03-25)
Mitochondria are the main cellular energy powerhouses and supply most of the energy in the form of ATP to fuel essential neuronal functions through oxidative phosphorylation (OXPHOS). In Alzheimer disease (AD), metabolic and mitochondrial disruptions are an early feature preceding
Produkty
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
Płytkowy czynnik wzrostu jest głównym mitogenem występującym w surowicy ssaków i jest uwalniany z płytek krwi podczas tworzenia skrzepu.
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej