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Kluczowe dokumenty
P0040
PP1
≥98% (HPLC)
Synonim(y):
4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
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About This Item
Wzór empiryczny (zapis Hilla):
C16H19N5
Numer CAS:
Masa cząsteczkowa:
281.36
Numer MDL:
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Próba
≥98% (HPLC)
Formularz
powder
kolor
white to off-white
rozpuszczalność
DMSO: >20 mg/mL
temp. przechowywania
room temp
ciąg SMILES
Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
InChI
1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
Klucz InChI
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Zastosowanie
PP1 has been used as:
- an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
- a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
- a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)
Działania biochem./fizjol.
PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.
PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.
Cechy i korzyści
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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