529576

PP2

InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases

• Synonim(y): InSolution PP2
• Wzór empiryczny (zapis Hilla): C₁₅H₁₆ClN₅
• Masa cząsteczkowa: 301.77
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: liquid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: clear colorless
• Warunki transportu: wet ice
• temp. przechowywania: −20°C

Opis

Opis ogólny

A potent and selective inhibitor of the src family of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56^lck (IC₅₀ = 4 nM), p59^fynT (IC₅₀ = 5 nM), and Hck (IC₅₀ = 5 nM) compared to other tyrosine kinases, such as EGF-R (IC₅₀ = 480 nM), JAK2 (IC₅₀ >50 µM) or ZAP-70 (IC₅₀ >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC₅₀ = 600 nM).

Działania biochem./fizjol.

Cell permeable: no

Primary Target
p56^lck

Product competes with ATP.

Reversible: yes

Target IC₅₀: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Irritant (B)

Postać fizyczna

A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529573) in DMSO.

Rekonstytucja

Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

Inne uwagi

Hanke, J.H., et al. 1996. J. Biol. Chem.271, 695.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 188.6 °F - (Dimethylsulfoxide)
• Temperatura zapłonu (°C): 87 °C - (Dimethylsulfoxide)