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N6252

Sigma-Aldrich

Norharmane

≥98% (TLC), crystalline, monoamine oxidase inhibitor

Synonim(y):

β-Carboline, 9H-Pyrido[3,4-b]indole

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About This Item

Wzór empiryczny (zapis Hilla):
C11H8N2
Numer CAS:
244-63-3
Masa cząsteczkowa:
168.19
Numer WE:
205-959-0
Numer MDL:
MFCD00004956
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24897776
NACRES:
NA.77

product name

Norharmane, crystalline

Postać

crystalline

Poziom jakości

200

kolor

light yellow

temp. przechowywania

2-8°C

ciąg SMILES

c1ccc2c(c1)[nH]c3cnccc23

InChI

1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H

Klucz InChI

AIFRHYZBTHREPW-UHFFFAOYSA-N

informacje o genach

human ... IKBKB(3551)
rat ... Gabra2(29706)

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Opis ogólny

Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.

Zastosowanie

Norharmane has been used:
  • as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
  • as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
  • as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)

Działania biochem./fizjol.

Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.
Inhibitor of indoleamine 2,3-dioxygenase (IDO).
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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