N1790

Naftifine hydrochloride

• Synonim(y): Naftifine HCL
• Wzór empiryczny (zapis Hilla): C₂₁H₂₁N · HCl
• Numer CAS: 65473-14-5
• Masa cząsteczkowa: 323.86
• Numer MDL: MFCD00059047
• Kod UNSPSC: 51102829
• Identyfikator substancji w PubChem: 329818590
• NACRES: NA.76

Właściwości

• Próba: ≥99%
• Postać: powder
• rozpuszczalność: ethanol: soluble 50 mg/mL
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• Tryb działania: cell wall synthesis | interferes; enzyme | inhibits
• temp. przechowywania: 2-8°C
• ciąg SMILES: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• Klucz InChI: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Opis

Zastosowanie

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Działania biochem./fizjol.

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): nwg
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable