T8826

Terbinafine hydrochloride

• Synonim(y): trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride
• Wzór empiryczny (zapis Hilla): C₂₁H₂₅N · HCl
• Numer CAS: 78628-80-5
• Masa cząsteczkowa: 327.89
• Numer MDL: MFCD00145430
• Kod UNSPSC: 51302503
• Identyfikator substancji w PubChem: 329826887
• NACRES: NA.85

Właściwości

• Próba: ≥98%
• Postać: powder
• kolor: white to faint beige
• rozpuszczalność: methanol: soluble 50 mg/mL
• spektrum działania antybiotyku: fungi; yeast
• Tryb działania: enzyme | inhibits
• ciąg SMILES: Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C
• InChI: 1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
• Klucz InChI: BWMISRWJRUSYEX-SZKNIZGXSA-N

Opis

Opis ogólny

Allylamine derivative.

Zastosowanie

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Działania biochem./fizjol.

Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.

Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Oświadczenie o zrzeczeniu się odpowiedzialności

The product is not intendedfor use as a biocide under global biocide regulations, including but notlimited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, EuropeanBiocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’sBiocidal Products Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS09
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H315,H319,H335,H410
• Zwroty wskazujące środki ostrożności: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves