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MTOXCE3A4
CypExpress™ 3A4 Cytochrome P450 human
Synonim(y):
CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450 3A4, P450C3, P450PCN1
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About This Item
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in Pichia pastoris
Formularz
dry powder
numer dostępu UniProt
Zastosowanie
cell analysis
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... CYP3A4(1576)
Zastosowanie
Poster: A Novel, Robust Recombinant Human P450 Biocatalytic System
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Działania biochem./fizjol.
Cytochrome P450 enzymes are heme containing monooxygenases which are found primarily in the mammalian liver. They catalyze the oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. Ketoconazole, itraconazole, azamulin, troleandomycin and verapamil are inhibitors, whereas rifampin is an inducer of the enzyme. The isozyme CYP3A4 is a major pathway for the invivo conversion of testosterone to 6β-Hydroxytestosterone via hydroxylation.
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds like xenobiotics, pollutants and drug molecules. Cytochrome P450 3A4 (CYP3A4) is one of the isoforms of cytochrome P450 (P450s). CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.
Cechy i korzyści
CypExpress™ 3A4 is a permeabilized and stabilized dried yeast powder preparation containing full length, unmodified, human CYP 3A4 and recombinant human NADPH oxidoreductase. Using proprietary processes, CypExpress™ are expressed in Pichia yeast. Following optimal expression, the cells are inactivated, permeabilized and dried to a fine powder. CypExpress™ retains the cellular mechanisms to provide the P450 enzymes with the energy and cofactors to continue to function for long experiments, and can generate larger amounts of metabolite than mammalian microsomes or other genetically engineered expression systems. It is designed for rapid screening of drug metabolites and for scaling up metabolite generation.
Definicja jednostki
A reaction mixture containing 500 μM testosterone and 100 mg/mL of CypExpress™ 3A4 will produce 121.9 μM 6b-hydroxytestosterone in 3 hours at 30°C under the conditions described.
Postać fizyczna
Light yellow, very fine powder
Rekonstytucja
Per Protocol/Variable
Informacje prawne
6538 is a trademark of American Type Culture Collection
CypExpress is a trademark of Oxford Biomedical Research
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produkt powiązany
Numer produktu
Opis
Cennik
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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