L1012

Linoleic acid

liquid, BioReagent, suitable for cell culture

• Synonim(y): cis-9,cis-12-Octadecadienoic acid
• Wzór liniowy: CH₃(CH₂)₄CH=CHCH₂CH=CH(CH₂)₇CO₂H
• Numer CAS: 60-33-3
• Masa cząsteczkowa: 280.45
• Beilstein: 1727101
• Numer WE: 200-470-9
• Numer MDL: MFCD00064241
• Kod UNSPSC: 12352211
• eCl@ss: 32190102
• Identyfikator substancji w PubChem: 24896270
• NACRES: NA.75

Właściwości

• pochodzenie biologiczne: plant (Safflower oil)
• linia produktu: BioReagent
• Próba: ≥98%
• Formularz: liquid
• metody: cell culture | mammalian: suitable
• współczynnik refrakcji: n20/D 1.466 (lit.)
• bp: 229-230 °C/16 mmHg (lit.)
• mp: −5 °C (lit.)
• rozpuszczalność: NaOH: 1 M; ethanol: soluble
• gęstość: 0.902 g/mL at 25 °C (lit.)
• temp. przechowywania: −20°C
• ciąg SMILES: OC(CCCCCCC/C=C\C/C=C\CCCCC)=O
• InChI: 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
• Klucz InChI: OYHQOLUKZRVURQ-HZJYTTRNSA-N
• informacje o genach: human ... SOAT1(6646) , SOAT2(8435)

Opis

Opis ogólny

Linoleic acid (LA) is the precursor for the synthesis of arachidonic prostaglandins and other eicosanoids. LA is present in vegetable oils and meat.

Zastosowanie

Fatty acid that is typically bound to a carrier molecule such as BSA or cyclodextrin for use in cell culture.

Linoleic acid has been used as a component of S12 medium for cardiomyocytes differentiation, minimum essential medium α for spermatogonial stem cell culture and for endothelial differentiation of mouse adipose-derived stem cells (mASC).

Działania biochem./fizjol.

Linoleic acid (LA) may improve wound healing in diabetic rat. The levels of LA in adipose tissue and platelets are correlated with coronary artery disease. It may induce tumor and apoptosis in colorectal cancer cells. Studies also support their protective effects in lymphocytes. Linoleic acid is typically bound to a carrier molecule such as bovine serum albumin (BSA) or cyclodextrin for use in cell culture.

Linoleic acid increases cell proliferation and gene expression of PPARα and its target genes such as acyl-CoA oxidase in primary duck hepatocytes .

Opakowanie

Sealed ampule.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)