K2015

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

• Synonim(y): SF 2370
• Wzór empiryczny (zapis Hilla): C₂₇H₂₁N₃O₅
• Numer CAS: 99533-80-9
• Masa cząsteczkowa: 467.47
• Numer WE: 200-664-3
• Numer MDL: MFCD00161522
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329817131
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: Nonomuraea longicatena
• Poziom jakości: 200
• Próba: >98%
• Postać: solution
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• Klucz InChI: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• informacje o genach: human ... NTRK1(4914) ; rat ... Prkca(24680)

Opis

Działania biochem./fizjol.

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Cechy i korzyści

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Postać fizyczna

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): 188.6 °F - closed cup
• Temperatura zapłonu (°C): 87 °C - closed cup
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)