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H7017
Hemocyanin from Megathura crenulata (keyhole limpet)
Synonim(y):
KLH, Keyhole limpet hemocyanin
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About This Item
Polecane produkty
pochodzenie biologiczne
Megathura crenulata
Poziom jakości
Formularz
powder
opakowanie
vial of KLH (KLH is present by weight at approximately 1 part KLH to 5 parts total solid.)
metody
ELISA: suitable
rozpuszczalność
H2O: soluble
temp. przechowywania
2-8°C
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Opis ogólny
Gastropod hemocyanins are massive glycoproteins (4 to 8 MDa) designed by an intricate arrangement of 10 subunits that are self-assembled into hollow cylinders 35 nm in diameter.
Hemocyanin is a high molecular weight copper containing glycoprotein. It reversibly binds oxygen and forms the extra-cellular respiratory protein of mollusks. Keyhole limpet hemocyanin (KLH) is filtered from the hemolymph of Megathura crenulata, also called the giant keyhole limpet. It is native to the southern California coast and Mexico.
Zastosowanie
Keyhole limpet hemocyanin (KLH) is a strong and well known immune-stimulant in both experimental animals and humans. It has been used as a hapten carrier protein to enhance antigen-specific T cell priming and is known to stimulate a CD4+ T-cell response. Hemocyanins stimulate Th1 reactions without known side effects, which make them ideal for long-term continuous treatment of cancer.
Postać fizyczna
Lyophilized with stabilizing buffer
Rekonstytucja
Reconstitute with deionized water to a KLH concentration of 10 mg/mL, to yield an opalescent solution in 31 mM sodium phosphate buffer, pH 7.4, containing 0.46 M NaCl, 2% PVP and 41 mM sucrose.
Reconstituted protein solution may be stored up to 2 months at −20 °C.
Reconstituted protein solution may be stored up to 2 months at −20 °C.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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