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Merck

H4131

Sigma-Aldrich

Hemoglobin porcine

lyophilized powder

Synonim(y):

Hb

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About This Item

Numer CAS:
Numer MDL:
Kod UNSPSC:
12352202
eCl@ss:
42030116
NACRES:
NA.61

pochodzenie biologiczne

Porcine

Poziom jakości

Postać

lyophilized powder

rozpuszczalność

H2O: soluble 10 mg/mL

numer dostępu UniProt

temp. przechowywania

2-8°C

informacje o genach

Opis ogólny

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

Zastosowanie

Hemoglobin from porcine was used to test the role of the L-arginine/nitric oxide pathway in relaxation of isolated human penile cavernous tissue and circumflex veins. It was also used to study the role of nitric oxide in neurogenic vasodilation of porcine cerebral artery.

Działania biochem./fizjol.

The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.
Oxygen transporter, NO scavenger

Przestroga

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


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F Y Chen et al.
The Journal of pharmacology and experimental therapeutics, 265(1), 339-345 (1993-04-01)
A superfusion bioassay cascade, with porcine pial arteries as donor tissues and rabbit aortic rings as detector tissues, was used to examine the role of nitric oxide (NO) in cerebral nonadrenergic, noncholinergic neurogenic vasodilation. All arteries were mechanically denuded of
H J Kirkeby et al.
Acta physiologica Scandinavica, 149(3), 385-392 (1993-11-01)
In human penile corpus cavernosum strips, pre-contracted by noradrenaline, electrical stimulation of nerves evoked non-adrenergic, non-cholinergic (NANC) relaxant responses which could be inhibited by tetrodotoxin 10(-6) M, NG-nitro-L-arginine (L-NNA) 10(-7)-10(-4) M, and oxyhaemoglobin 10(-5) M, but not by methylene blue
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