G013

R(+)-Baclofen hydrochloride

solid

• Synonim(y): Arbaclofen hydrochloride, R(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride, STX209
• Wzór empiryczny (zapis Hilla): C₁₀H₁₂ClNO₂ · HCl
• Numer CAS: 63701-55-3
• Masa cząsteczkowa: 250.12
• Numer MDL: MFCD00078579
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24895006
• NACRES: NA.32

Właściwości

• Postać: solid
• Poziom jakości: 100
• aktywność optyczna: [α]28/D +3.8°, c = 0.9 in methanol(lit.)
• warunki przechowywania: desiccated
• kolor: white
• rozpuszczalność: DMSO: >20 mg/mL; H₂O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)
• ciąg SMILES: Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1
• InChI: 1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
• Klucz InChI: WMNUVYYLMCMHLU-QRPNPIFTSA-N
• informacje o genach: human ... GABBR1(2550) ; mouse ... GABBR1(54393) ; rat ... GABBR1(81657)

Opis

Zastosowanie

R(+)-Baclofen hydrochloride has been used as a GABA_B receptor agonist to study its effects on M43068-induced antinociception in rat models. It has also been used as a GABA_B receptor agonist to study its effects on amphetamine-induced behavior and neurochemical responses in rat striatum.

Działania biochem./fizjol.

Baclofen is a derivative of γ-aminobutyric acid (GABA) and acts as a 4-aminobutanoic acid receptor (GABA_B) agonist. It interacts stereospecifically with the GABA receptor and exhibits antispastic effects.Baclofen shows therapeutic effects against paroxysmal pain of trigeminal neuralgia and spinal spasticity. R(+)-Baclofen is a more active enantiomer.

Inne uwagi

Same enantiomer as R(−)-baclofen free base.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)