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Key Documents

F5386

Sigma-Aldrich

Fibrin from human plasma

insoluble powder

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About This Item

Numer CAS:
9001-31-4
Numer WE:
232-597-0
Numer MDL:
MFCD00131058
Kod UNSPSC:
12352202
NACRES:
NA.61

pochodzenie biologiczne

human plasma

Poziom jakości

200

Postać

powder

metody

indirect ELISA: suitable

numer dostępu UniProt

P02671
P02675
P02679

InChI

1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)

Klucz InChI

BWGVNKXGVNDBDI-UHFFFAOYSA-N

informacje o genach

human ... FGA(2243) , FGB(2244) , FGG(2266)

Opis ogólny

Fibrin is produced from cross-linking of fibrinogen by thrombin. Fibrinogen is made up of two monomers each containing three polypeptide chains. Fibrinogen is a major plasma protein.

Zastosowanie

Fibrin from human plasma has been used:
  • for in vitro cleavage of fibrinogen and fibrin
  • as a reference for true component analysis (TCA) and principal component analysis (PCA) of Raman spectra
  • as a reference in Raman spectroscopy to study the binding mechanisms and the binding efficiency of the different polyoxometalates (POMs)

Działania biochem./fizjol.

Fibrin acts as an important bio-polymer in the primary blood clotting process. It creates a scaffold for infiltrating cells during tissue repair. Fibrin is widely used as a tissue sealant for tissue regeneration applications as it enables the formation of a biocompatible physical structure. It is also used in delivery systems for cells and bioactive molecules. The fibrin matrix resembles the native pancreas and can serve as a scaffold material for islet transplantation. Fibrin has been used in studies to obtain fibrin-specific monoclonal antibodies (mAbs). These mAbs may be used to determine their role in fibrin polymerization and use in fibrin quantification in blood plasma.

Uwaga dotycząca przygotowania

Prepared by clotting fibrinogen to yield a crosslinked fibrin

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Coagulation Factor XIII, Human Plasma Coagulation Factor XIII, Human Plasma, CAS 9013-56-3, is a native tetrameric form composed of two identical α- and two β-subunits. Thrombin converts the α2β2 tetramer to a modified α2ʹβ2 tetramer.

Sigma-Aldrich

233501-M

Coagulation Factor XIII, Human Plasma

D-dimer, Human from human plasma, buffered aqueous solution

Sigma-Aldrich

D9321

D-dimer, Human

Thrombin from human plasma lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280, 18.3)

Sigma-Aldrich

T6884

Thrombin from human plasma

Weimin Wu et al.
The Journal of investigative dermatology, 134(1), 256-263 (2013-07-24)
Dermatopontin (DP) is a small extracellular matrix component in the dermis. Fibrin is a major component of a provisional matrix that is formed just after wounding. Previously, we found that DP was present in the provisional matrix, and it interacted
Abraham R Alfonso et al.
Acta biomaterialia, 9(9), 8149-8157 (2013-06-26)
Tissue engineered heart valves (TEHVs) may provide a permanent solution to congenital heart valve disease by permitting somatic valve growth in the pediatric patient. However, to date, TEHV studies have focused primarily on collagen, the dominant component of valve extracellular
James C Fredenburgh et al.
The Journal of biological chemistry, 288(41), 29394-29402 (2013-08-31)
The nonspecific binding of heparin to plasma proteins compromises its anticoagulant activity by reducing the amount of heparin available to bind antithrombin. In addition, interaction of heparin with fibrin promotes formation of a ternary heparin-thrombin-fibrin complex that protects fibrin-bound thrombin
Kristen T Morin et al.
Experimental cell research, 319(16), 2409-2417 (2013-06-27)
In vitro models of endothelial assembly into microvessels are useful for the study of angiogenesis and vasculogenesis. In addition, such models may be used to provide the microvasculature required to sustain engineered tissues. A large range of in vitro models
Matteo Centola et al.
Tissue engineering. Part A, 19(17-18), 1960-1971 (2013-04-25)
Standard cartilage tissue engineering approaches, for example, matrix-induced autologous chondrocyte implantation (MACI), consist of the implantation of cell-based constructs whose survival and further development first depend on the degree of graft maturity at the time of surgery (e.g., matrix production)
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