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D0540

Sigma-Aldrich

DNQX

≥98% (TLC)

Synonim(y):

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

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About This Item

Wzór empiryczny (zapis Hilla):
C8H4N4O6
Numer CAS:
2379-57-9
Masa cząsteczkowa:
252.14
Numer MDL:
MFCD00069257
Kod UNSPSC:
51111800
Identyfikator substancji w PubChem:
24277973
NACRES:
NA.77

Poziom jakości

200

Próba

≥98% (TLC)

Postać

powder

ciąg SMILES

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O

InChI

1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

Klucz InChI

RWVIMCIPOAXUDG-UHFFFAOYSA-N

informacje o genach

human ... GRIA1(2890) , GRIA2(2891) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592) , Grik1(29559) , Grik4(24406) , Grin2a(24409)

Zastosowanie

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.

Działania biochem./fizjol.

DNQX is a quinoxaline derivative.
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Cechy i korzyści

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This page may contain text that has been machine translated.

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Odwiedź Bibliotekę dokumentów

J Waider et al.
Translational psychiatry, 7(10), e1246-e1246 (2017-10-04)
Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice.
Differential Desensitization Observed at Multiple Effectors of Somatic mu-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity
Fox PD and Hentges ST
The Journal of Neuroscience, 37(36), 8667-8677 (2017)
Chuanqiang Zhang et al.
BMC biology, 17(1), 95-95 (2019-11-30)
Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain. A widely used inhibitory optogenetic actuator is eNpHR3.0, an improved version of the light-driven chloride pump halorhodopsin
Rei Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)
Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus
Focal activation of neuronal circuits induced by microstimulation in the visual cortex
Tanaka Y, et al.
Journal of Neural Engineering, 16(3), 036007-036007 (2019)
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