Przejdź do zawartości
Merck
Wszystkie zdjęcia(1)

Key Documents

Inne dokumenty

C127

Sigma-Aldrich

CNQX

≥98% (HPLC), solid

Synonim(y):

6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(1)

About This Item

Wzór empiryczny (zapis Hilla):
C9H4N4O4
Numer CAS:
115066-14-3
Masa cząsteczkowa:
232.15
Numer MDL:
MFCD00069232
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24892392
NACRES:
NA.77

Poziom jakości

100

Próba

≥98% (HPLC)

Postać

solid

warunki przechowywania

protect from light

kolor

yellow

rozpuszczalność

DMSO: >10 mg/mL
H2O: insoluble

ciąg SMILES

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

Klucz InChI

RPXVIAFEQBNEAX-UHFFFAOYSA-N

informacje o genach

rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409)

Zastosowanie

CNQX has been used:
  • as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
  • glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
  • as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats

Działania biochem./fizjol.

Potent, competitive AMPA/kainate glutamate receptor antagonist.

Inne uwagi

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Klienci oglądali również te produkty

Slide 1 of 6

1 of 6

(+)-MK-801 hydrogen maleate powder

Sigma-Aldrich

M107

(+)-MK-801 hydrogen maleate

Picrotoxinin European Pharmacopoeia (EP) Reference Standard

Y0001528

Picrotoxinin

CGP 55845 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0594

CGP 55845 hydrochloride

(+)-Bicuculline ≥97.0% (TLC)

Sigma-Aldrich

14340

(+)-Bicuculline

(+)-Bicuculline phyproof® Reference Substance

PHL80371

(+)-Bicuculline

1(S),9(R)-(−)-Bicuculline methiodide ≥95.0% (HPCE)

Sigma-Aldrich

14343

1(S),9(R)-(−)-Bicuculline methiodide

Guan Hock Khoo et al.
Molecular neurobiology, 56(9), 6436-6450 (2019-03-04)
Long-term depression (LTD) of synaptic efficacy is widely regarded as a cellular basis of learning and memory. The magnitude of hippocampal CA1 LTD induced by low-frequency stimulation (LFS) declines with age, but the mechanisms involved remain poorly understood. Perineuronal nets
Binbin Yan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
Ira Espuny-Camacho et al.
Neuron, 77(3), 440-456 (2013-02-12)
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
Xiang Zeng et al.
Biomaterials, 53, 184-201 (2015-04-22)
Functional deficits following spinal cord injury (SCI) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after spinal cord transection (SCT). Rat bone marrow-derived mesenchymal
Wyświetl wszystkie powiązane dokumenty

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej