AV33672

Anti-NR1H4 antibody produced in rabbit

affinity isolated antibody

• Synonim(y): Anti-Nuclear receptor subfamily 1, group H, member 4
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: 54 kDa
• reaktywność gatunkowa: guinea pig, horse, bovine, rat, human, mouse, dog
• stężenie: 0.5 mg - 1 mg/mL
• metody: immunohistochemistry: suitable; western blot: suitable
• numer dostępu NCBI: NP_005114
• numer dostępu UniProt: Q96RI1-2
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... NR1H4(9971)

Opis

Opis ogólny

Farnesoid X receptor (FXR/NR1H4) belongs to the nuclear receptor (NR) superfamily. It is a receptor of bile acids (BAs). FXR is expressed in liver, intestine, kidney and adrenal gland. This gene is located on human chromosome 12q23. It has n N-terminal DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD).

Immunogen

Synthetic peptide directed towards the middle region of human NR1H4

Działania biochem./fizjol.

The NR1H4 gene encodes a protein that has a central role in lipid homeostasis and also regulates carbohydrate metabolism.

The ligand-activated transcription factor farnesoid X receptor (FXR/NR1H4) plays a key role in metabolic regulation and liver protection. FXR modulates bile acid, lipid and glucose metabolism. It participates in the modulation of bile acid synthesis, secretion and transport. Mutation in this gene results in familial intrahepatic cholestasis.

Sekwencja

Synthetic peptide located within the following region: AECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKT

Postać fizyczna

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable