AC-0363

SPINK1 (TATI, PSTI) (EP401) Rabbit Monoclonal Primary Antibody

• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• forma przeciwciała: Ig fraction of antiserum
• klon: monoclonal
• opis: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Postać: buffered aqueous solution
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• Warunki transportu: wet ice
• temp. przechowywania: 2-8°C
• wizualizacja: cytoplasmic

Opis

Opis ogólny

Serine protease inhibitor Kazal-type 1 (SPINK1), also known as tumor-associated trypsin inhibitor (TATI) and pancreatic secretory trypsin inhibitor (PSTI) is a cytosolic trypsin inhibitor secreted by pancreatic acinar cells and foveolar cells of the stomach that protects the gastrointestinal system from premature trypsinogen auto-digestion. Mutations in SPINK1 are associated with hereditary pancreatitis. Recently, SPINK1 demonstrated utility in differentiating hepatocellular carcinoma (HCC) from precancerous lesions. SPINK1 is detected in all hereditary haemochromatosis HCC and most (79%) of HCC cases, but limited to the luminal surface of large bile ducts in normal liver. SPINK1 expression is also detected in neoplasms of the ovary, bladder, kidney, pancreas, colon, lung, and breast. High expression of SPINK1 is often associated with advanced tumor staging, making it a useful prognostic marker.

Jakość

IVD

IVD

IVD

RUO

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide

Inne uwagi

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable