A3262

Adenosine 3′,5′-cyclic monophosphate tris salt

≥97% (HPLC), powder

• Synonim(y): cAMP, cyclic AMP
• Wzór empiryczny (zapis Hilla): C₁₀H₁₂N₅O₆P · C₄H₁₁NO₃
• Numer CAS: 102029-77-6
• Masa cząsteczkowa: 450.34
• Numer MDL: MFCD00058346
• Kod UNSPSC: 41106305
• eCl@ss: 32160414
• Identyfikator substancji w PubChem: 329770822
• NACRES: NA.51

Właściwości

• pochodzenie biologiczne: synthetic
• Próba: ≥97% (HPLC)
• Postać: powder
• kolor: white
• rozpuszczalność: H₂O: 100 mg/mL
• temp. przechowywania: −20°C
• ciąg SMILES: NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
• InChI: 1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1
• Klucz InChI: CLDDYJFNXTUHIN-MCDZGGTQSA-N

Opis

Opis ogólny

Adenosine 3′,5′-cyclic monophosphate (cAMP) is synthesized from ATP in the presence of Adenylate cyclase enzyme. cAMP is majorly used as a marker in immunochemical detection assays. Intracellular levels of cAMP control immune and inflammatory functions. Bacterial infection triggers intracellular cAMP production. Elevated levels of cAMP modulates mitogen-activated protein kinase (MAPK) in cancer. An altered cAMP level is implicated in pathogenesis of cataract and cardiovascular disease. A decrease in cAMP levels triggers impaired insulin secretion in diabetes.

Zastosowanie

Adenosine 3′,5′-cyclic monophosphate tris salt has been used as a medium supplement for human endometrial stromal cells (hESCs) culture and induced neural stem cells (iNSCs). It has been used in the spectroscopic characterization of pink flamindo, a red cAMP indicator.

Działania biochem./fizjol.

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)