30970

Sodium deoxycholate

BioXtra, ≥98.0% (dry matter, NT)

• Synonim(y): 3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt
• Wzór empiryczny (zapis Hilla): C₂₄H₃₉NaO₄
• Numer CAS: 302-95-4
• Masa cząsteczkowa: 414.55
• Beilstein: 3581950
• Numer WE: 206-132-7
• Numer MDL: MFCD00064139
• Kod UNSPSC: 12161900
• Identyfikator substancji w PubChem: 57648497
• NACRES: NA.21

Właściwości

• pochodzenie biologiczne: ox bile
• Poziom jakości: 300
• opis: anionic
• linia produktu: BioXtra
• Próba: ≥98.0% (dry matter, NT)
• Postać: powder
• aktywność optyczna: [α]20/D +44±2°, c = 2% in H₂O
• masa cząsteczkowa: micellar avg mol wt 1200-5000
• liczba agregacji: 3-12
• metody: DNA purification: suitable; RNA purification: suitable; electrophoresis: suitable
• zanieczyszczenia: ≤1% cholic acid (HPLC); ≤6% water
• CMC: 2-6 mM (20-25°C)
• rozpuszczalność: water: soluble 1 gm in 10 ml, clear, colorless to very faintly yellow
• ślady kationów: Ca: ≤500 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤10 mg/kg; Mg: ≤10 mg/kg; Mn: ≤5 mg/kg; Ni: ≤5 mg/kg; Pb: ≤10 mg/kg; Zn: ≤5 mg/kg
• HLB: 16
• grupa funkcyjna: carboxylic acid
• ciąg SMILES: [Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
• Klucz InChI: FHHPUSMSKHSNKW-SMOYURAASA-M

Opis

Opis ogólny

Sodium Deoxycholate, a bile acid derivative, is a crucial component in biochemical and cell biology research. This water-soluble detergent is widely used in protein-related experiments, including cell lysates and liposome preparation. It aids in membrane protein extraction, lipid compound extraction, and cell nucleus separation. Sodium Deoxycholate is also applied in cholesterol flocculation tests and affinity chromatography for column elution or regeneration. It is commonly used in microbiology for cell lysing, especially because it can be removed from the solution via dialysis.

Sodium Deoxycholate is also utilized in eluting buffers for affinity chromatography and plays a crucial role in DNA and RNA extraction from cells and tissues in molecular biology applications. Additionally, it is used as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Zastosowanie

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Działania biochem./fizjol.

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells as well as increased serosal absorption of epirubicin in the rat jejunum and ileum. Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.

Cechy i korzyści

• Suitable for Cell Biology and Biochemical Research
• Can be used in Electrophoresis, DNA and RNA purification
• Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications.
• High purity product for research applications

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P312 - P501
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves