Y0001761

Nicorandil

European Pharmacopoeia (EP) Reference Standard

• Synonim(y): 2-(Pyridine-3-carbonylamino)ethyl nitrate, 2-Nicotinamidoethyl nitrate, Ikorel, N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide, SG-75, Sigmart, Zynicor
• Wzór empiryczny (zapis Hilla): C₈H₉N₃O₄
• Numer CAS: 65141-46-0
• Masa cząsteczkowa: 211.17
• Numer MDL: MFCD00186520
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329831558
• NACRES: NA.24

Właściwości

• klasa czystości: pharmaceutical primary standard
• rodzina API: nicorandil
• producent / nazwa handlowa: EDQM
• Zastosowanie: pharmaceutical (small molecule)
• format: neat
• temp. przechowywania: −20°C
• ciąg SMILES: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• Klucz InChI: LBHIOVVIQHSOQN-UHFFFAOYSA-N

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Nicorandil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Działania biochem./fizjol.

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H242,H302
• Zwroty wskazujące środki ostrożności: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Org. Perox. D
• Kod klasy składowania: 5.2 - Organic peroxides and self-reacting hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable