T4062

Tetracycline hydrochloride

meets USP testing specifications

• Synonim(y): Tetracycline HCL
• Wzór empiryczny (zapis Hilla): C₂₂H₂₄N₂O₈ · HCl
• Numer CAS: 64-75-5
• Masa cząsteczkowa: 480.90
• Beilstein: 3844873
• Numer WE: 200-593-8
• Numer MDL: MFCD00078142
• Kod UNSPSC: 51284043
• Identyfikator substancji w PubChem: 24900192
• NACRES: NA.76

Właściwości

• agency: USP/NF; meets USP testing specifications
• Poziom jakości: 200
• Próba: ≥900 (Units in µg/mg)
• Formularz: crystalline powder
• aktywność optyczna: [α]/D -255 to 240° (Specific rotation )
• warunki przechowywania: (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
• zanieczyszczenia: ≤4.0%
• kolor: yellow
• mp: 220-223 °C (lit.)
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria
• Zastosowanie: pharmaceutical (small molecule)
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: −20°C
• ciąg SMILES: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
• Klucz InChI: XMEVHPAGJVLHIG-FMZCEJRJSA-N

Opis

Opis ogólny

Chemical structure: tetracycline

Zastosowanie

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.

Działania biochem./fizjol.

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Przestroga

This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.

Uwaga dotycząca przygotowania

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07,GHS09
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H315,H319,H335,H361fd,H410
• Zwroty wskazujące środki ostrożności: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Klasyfikacja zagrożeń: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves