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PHR1359

Supelco

Glutathione

Pharmaceutical Secondary Standard; Certified Reference Material

Synonim(y):

L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine, GSH

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About This Item

Wzór liniowy:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Numer CAS:
Masa cząsteczkowa:
307.32
Beilstein:
1729812
Numer WE:
Numer MDL:
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
NACRES:
NA.24

klasa czystości

certified reference material
pharmaceutical secondary standard

Poziom jakości

agency

traceable to Ph. Eur. Y0000517
traceable to USP 1294820

rodzina API

glutathione

Certyfikat analizy

current certificate can be downloaded

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

192-195 °C (dec.) (lit.)

Zastosowanie

pharmaceutical (small molecule)

format

neat

temp. przechowywania

2-30°C

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Amino Acid Sequence

γ-Glu-Cys-Gly

Opis ogólny

Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms.[1] GSH is also a key determinant of redox signaling and protection against oxidative stress.[2]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Zastosowanie

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Działania biochem./fizjol.

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAA7940 in the slot below. This is an example certificate only and may not be the lot that you receive.

Polecane produkty

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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    Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

    Odwiedź Bibliotekę dokumentów

    Glutathione: an overview of biosynthesis and modulation
    Anderson ME
    Chemico-Biological Interactions, 111, 1-14 (1998)
    The glutathione status of cells
    International Review of Cytology, 54, 109-160 (1978)
    Dalia Gritenaite et al.
    Genes & development, 28(14), 1604-1619 (2014-07-18)
    A key function of the cellular DNA damage response is to facilitate the bypass of replication fork-stalling DNA lesions. Template switch reactions allow such a bypass and involve the formation of DNA joint molecules (JMs) between sister chromatids. These JMs
    Karen Shahbabian et al.
    Nucleic acids research, 42(13), 8692-8704 (2014-07-12)
    Messenger RNA (mRNA) localization is coupled to the translational repression of transcripts during their transport. It is still unknown if this coupling depends on physical interactions between translational control and mRNA localization machineries, and how these interactions are established at
    Julien Viaud et al.
    Nature communications, 5, 4080-4080 (2014-06-07)
    PtdIns5P is a lipid messenger acting as a stress-response mediator in the nucleus, and known to maintain cell activation through traffic alterations upon bacterial infection. Here, we show that PtdIns5P regulates actin dynamics and invasion via recruitment and activation of

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