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Key Documents
G6257
Glutaraldehyde solution
Grade II, 25% in H2O
Synonim(y):
Glutaric dialdehyde solution, Pentane-1,5-dial
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About This Item
Wzór liniowy:
OHC(CH2)3CHO
Numer CAS:
Masa cząsteczkowa:
100.12
Beilstein:
605390
Numer MDL:
Kod UNSPSC:
12352114
Identyfikator substancji w PubChem:
NACRES:
NA.21
Polecane produkty
typ
Grade II
Poziom jakości
Postać
liquid
stężenie
25% in H2O
metody
electron microscopy: suitable
kolor
colorless
przydatny zakres pH
2.9
mp
-10 °C ((14 °F ))
rozpuszczalność
water: soluble
Zastosowanie
cell analysis
sample preparation
ciąg SMILES
[H]C(CCCC([H])=O)=O
InChI
1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
Klucz InChI
SXRSQZLOMIGNAQ-UHFFFAOYSA-N
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Opis ogólny
Glutaraldehyde, known as Glutaric dialdehyde or Pentane-1,5-dial, serves as a versatile reagent with applications spanning various research domains, including cell biology and biochemical research. It finds applications as a protein crosslinker, aids in enzyme immobilization for microscopy, and contributes to histochemistry and cytochemistry processes. As an amine-reactive homobifunctional crosslinker, it acts as a cell fixative before procedures like SDS-PAGE, staining, or electron microscopy, making it a valuable tool for diverse morphological studies.
Glutaraldehyde demonstrates efficacy in crosslinking amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it allows direct coupling of biotin hydrazides to nucleic acids, offering potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. Moreover, in histology studies, Glutaraldehyde is employed for preserving tissue sections and preparing them for detailed examination.
Glutaraldehyde demonstrates efficacy in crosslinking amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it allows direct coupling of biotin hydrazides to nucleic acids, offering potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. Moreover, in histology studies, Glutaraldehyde is employed for preserving tissue sections and preparing them for detailed examination.
Zastosowanie
Glutaraldehyde solution has been used:
- for fixation of mouse and esophageal cancer cell lines
- to crosslink amyloid-β protein
- to crosslink gelatin in 3D scaffold preparation of trachea
Działania biochem./fizjol.
Glutaraldehyde is an effective protein crosslinker and finds application in techniques like enzyme immobilisation microscopy, histochemistry and cytochemistry. It exists in different forms under acidic or neutral conditions. It is toxic to aquatic organisms. Its allergic nature leads to hypersensitivity reactions. Contact of glutaraldehyde vapors in endoscopy contributes to Colitis.
Cechy i korzyści
- Versatile and adaptable for wide variety of research applications
- Ready-made solution reduces the need for preparation time
Opakowanie
Not refrigerated en route
Przestroga
This grade is not recommended for use as an electron microscopy fixative.
Uwaga dotycząca przygotowania
Not specially purified.
Inne uwagi
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Oświadczenie o zrzeczeniu się odpowiedzialności
“The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.”
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produkt podobny
Numer produktu
Opis
Cennik
Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
Organy docelowe
Respiratory system
Zagrożenia dodatkowe
Kod klasy składowania
8A - Combustible corrosive hazardous materials
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin
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Biomedicine and Pharmacotherapy, 67(5), 417-424 (2013)
Sorption characteristics of mixed molecules of glutaraldehyde from water on mesoporous acid-amine modified low-cost activated carbon: mechanism, isotherm, and kinetics
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