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Merck

G5882

Sigma-Aldrich

Glutaraldehyde solution

Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative

Synonim(y):

Glutaric dialdehyde solution, Pentane-1,5-dial

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About This Item

Wzór liniowy:
OHC(CH2)3CHO
Numer CAS:
Masa cząsteczkowa:
100.12
Beilstein:
605390
Numer MDL:
Kod UNSPSC:
12352114
Identyfikator substancji w PubChem:
NACRES:
NA.21

Poziom jakości

typ

Grade I

Formularz

liquid

stężenie

25% in H2O

metody

electron microscopy: suitable (fixative)
electron microscopy: suitable

kolor

colorless

przydatny zakres pH

2.9

mp

-10 °C ((14 °F ))

rozpuszczalność

water: soluble at 20 °C

Zastosowanie

cell analysis

Warunki transportu

dry ice

temp. przechowywania

−20°C

ciąg SMILES

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

Klucz InChI

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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Opis ogólny

Glutaraldehyde (Glutaric dialdehyde, Pentane-1,5-dial) is an aliphatic dialdehyde widely utilized as a versatile biochemical reagent. Glutaraldehyde solutions contain both monomers and polymers with the difference in their fixation properties. Its applications include serving as a protein crosslinker, facilitating enzyme immobilization in microscopy, histochemistry, and cytochemistry. This compound acts as an amine-reactive homobifunctional crosslinker and a cell fixative before SDS-PAGE, staining, or electron microscopy, making it suitable for diverse morphological studies.
Glutaraldehyde efficiently crosslinks amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it has been used in certain reactions to directly couple biotin hydrazides to nucleic acids, suggesting potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is employed to preserve tissue sections, preparing them for closer examination.

Zastosowanie

Glutaraldehyde solution has been used:
  • to fix the blood samples for scanning electron microscopy (SEM)
  • to fix scaffold pieces for SEM analysis
  • in drug treatments to treat K562 (leukemia) cells to permanently cross-link cell components

Działania biochem./fizjol.

Glutaraldehyde can be used in biomedical research to fix cells. It can also be used as a tool to investigate healthy and pathologic red blood cells. Medical equipment like spirometry tubing, endoscopes, dialyzers, hemodialysis proportioning and dialysate delivery systems, endocavitary probes, transducers, anesthesia and respiratory therapy equipment, and reuse of laparoscopic disposable plastic trocars can be disinfected with glutaraldehyde.

Cechy i korzyści

  • Versatile and adaptable for wide variety of research applications
  • Ready-made solution reduces the need for preparation time

Inne uwagi

For additional information on our range of Biochemicals, please complete this form.
Recommended for techniques demanding high purity.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Organy docelowe

Respiratory system

Kod klasy składowania

8A - Combustible corrosive hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Środki ochrony indywidualnej

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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