BP854

Chloramphenicol

British Pharmacopoeia (BP) Reference Standard

• Synonim(y): D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin
• Wzór liniowy: Cl₂CHCONHCH(CH₂OH)CH(OH)C₆H₄NO₂
• Numer CAS: 56-75-7
• Masa cząsteczkowa: 323.13
• Beilstein: 2225532
• Numer WE: 200-287-4
• Numer MDL: MFCD00078159
• Kod UNSPSC: 41116107
• NACRES: NA.24

Właściwości

• klasa czystości: pharmaceutical primary standard
• rodzina API: chloramphenicol
• Postać: powder
• okres trwałości: limited shelf life, expiry date on the label
• producent / nazwa handlowa: BP
• mp: 149-153 °C (lit.)
• Zastosowanie: pharmaceutical; pharmaceutical small molecule
• format: neat
• temp. przechowywania: 2-8°C
• ciąg SMILES: OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
• InChI: 1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
• Klucz InChI: WIIZWVCIJKGZOK-RKDXNWHRSA-N

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Chloramphenicol BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Chloramphenicol Eye Drops

Chloramphenicol Sodium Succinate Injection

Chloramphenicol Capsules

Chloramphenicol Ear Drops

Chloramphenicol Eye Ointment

Działania biochem./fizjol.

Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

Opakowanie

Unit quantity: 500 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Inne uwagi

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS05
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H318,H351,H361fd
• Zwroty wskazujące środki ostrożności: P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501
• Klasyfikacja zagrożeń: Carc. 2 - Eye Dam. 1 - Repr. 2
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3