SCT264
BioTracker™ Mitophagy Live Cell Probe
Human
Synonim(y):
mitochondrial degradation probe, mitophagy detection, mitophagy probe
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About This Item
Kod UNSPSC:
41106514
NACRES:
NB.12
Polecane produkty
product name
BioTracker™ Mitophagy Live Cell Probe,
pochodzenie biologiczne
human
Poziom jakości
Postać
lyophilized solid
opakowanie
vial of 15 μg
producent / nazwa handlowa
Millipore
metody
cell culture | stem cell: suitable
Warunki transportu
2-8°C
temp. przechowywania
2-8°C
Opis ogólny
The Mitophagy probe accumulates in intact mitochondria, where it is immobilized by chemical bonds and exhibits a weak fluorescence under normal conditions. When mitophagy is induced, the damaged mitochondria fuse with the lysosome, increasing fluorescence
SPECTRAL PROPERTIES
λex: 530 nm
λem: 700 nm
A 100 uM stock solution of the mitophagy probe is created by dissolving 50 uL DMSO to one tube (5 ug) of mitophagy dye.
A typical working solution concentration is 1 nM.
SPECTRAL PROPERTIES
λex: 530 nm
λem: 700 nm
A 100 uM stock solution of the mitophagy probe is created by dissolving 50 uL DMSO to one tube (5 ug) of mitophagy dye.
A typical working solution concentration is 1 nM.
Cechy i korzyści
SCT264 live cell mitophagy detection probe accumulates and is immobilized on intact mitochondria, which fuse to the lysosome after mitophagy is induced, causing the probe to fluoresce brightly. Mitophagy has been associated with the accumulation of dysfunctional mitochondria in diseases such Alzheimer′s and Parkinson′s.
Opis wartości docelowych
Mitochondria play an essential role in cells for the production of energy. Mitophagy, or the removal of damaged mitochondria via autophagy, has been connected to Alzheimer s and Parkinson s disease induced by the accumulation of depolarized mitochondria. Mitophagy serves as a dedicated elimination system that removes mitochondria whose dysfunction may be caused by oxidative stress and DNA damage. Mitochondria destined for autophagy are sequestered into the autophagosome, fused to the lysosome, and digested.
Postać fizyczna
purple solid
Przechowywanie i stabilność
Store at 2 - 8 °C, protected from light.
Inne uwagi
This far red live cell probe for mitophagy detection fluoresces brightly when damaged mitochondria enter the acidic environment of the lysosome.
Informacje prawne
BioTracker is a trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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