MATFLAGELLIN

NEP Control Flagellin- PyroMAT^® System MAT

Non-endotoxin pyrogen control of flagellin for use in monocyte activation test

• Synonim(y): NEP, NEP Control
• Kod UNSPSC: 41116130
• eCl@ss: 32160606
• NACRES: NA.24

Właściwości

• Próba: ≥95% (SDS-PAGE)
• Poziom jakości: 400
• zastosowanie: sufficient for 10 tests
• Właściwości: Non-endotoxin pyrogen control of flagellin for use in monocyte activation test
• producent / nazwa handlowa: PyroMAT^®
• Zastosowanie: pharmaceutical; pyrogen testing
• kompatybilność: configured for PyroDetect System; configured for PyroMAT^® System
• Warunki transportu: cooler
• temp. przechowywania: −20°C
• przydatność: pyrogenic bacteria

Opis

Opis ogólny

The PyroMAT^® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs)is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA.
NEP control flagellin is a preparation of flagellin from Salmonella typhimurium and supplied in a lyophilized form. Flagellin is a non-endotoxin pyrogen (NEP) that activates the TLR5 receptor of monocytes and can be used as a positive control with the PyroMAT^® System (Monocyte Activation Test for pyrogen detection).

Specyficzność

TLR-5 agonist

Zastosowanie

NEP control of flagellin can be used as a positive control with the PyroMAT^® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.

Cechy i korzyści

Endotoxin-free product at concentration of use in MAT Purity: ≥ 95% (SDS-PAGE)

Przechowywanie i stabilność

Store unopened vials at -20°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Shelf life of aliquots can be found on the technical datasheet

Informacje prawne

PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable