MABS502
Anti-CYP11B1 Antibody, clone 80-7
clone 80-7, from rat
Synonim(y):
Cytochrome P450 11B1, mitochondrial, CYPXIB1, Cytochrome P-450c11, Cytochrome P450C11, Steroid 11-beta-hydroxylase, CYP11B1
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rat
Poziom jakości
forma przeciwciała
purified antibody
rodzaj przeciwciała
primary antibodies
klon
80-7, monoclonal
reaktywność gatunkowa
human, rat
metody
immunohistochemistry: suitable
western blot: suitable
izotyp
IgG2aκ
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... CYP11B1(1584)
Opis ogólny
Cytochrome P450 11B1, mitochondrial (EC1.14.15.4, EC1.14.15.5; UniProt P15538; also known as CYPXIB1, Cytochrome P-450c11, Cytochrome P450C11, Cytochrome P450 subfamily XIB polypeptide 1, Cytochrome P450 XIB1, Steroid 11-beta-monooxygenase, Steroid 11-beta-hydroxylase) is encoded by the CYP11B1 (Also known as CPN1, CYP11B, FHI, P450C11, S11BH) gene in human (Gene ID 1584). CYP11B1 protein is a member of the cytochrome P450 superfamily of monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It is localized to the inner mitochondrial membrane and mediates the conversion of progesterone to cortisol in the adrenal cortex. CYP11B1 gene mutations are known causes of adrenal hyperplasia 4 (AH4), a form of congenital adrenal hyperplasia due to defective synthesis of cortisol.
Immunogen
Chicken serum albumin-conjugated linear peptide corresponding to human CYP11B1 near the N-terminus.
Epitope: Near N-terminus
Zastosowanie
Anti-CYP11B1 Antibody, clone 80-7 is an antibody against CYP11B1 for use in Western Blotting and Immunohistochemistry.
Research Category
Signaling
Signaling
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected exogenously expressed human CYP11B1, but not CYP11B1 in 10 µg of HEK293 cell lysate.
Western Blotting Analysis: A representative lot detected transfected CYP11B1 in HEK293 cells and endogenous CYP11B1 in mitochondrial preparation from human adrenocortical cell line HAC15 (Gomez-Sanchez, C.E., et al. 2014 Mol. Cell. Endocrinol. 383(1-2):111-117).
Immunohistochemistry Analysis: A representative lot detected CYP11B1 in normal human adrenal tissue.
Western Blotting Analysis: A representative lot detected transfected CYP11B1 in HEK293 cells and endogenous CYP11B1 in mitochondrial preparation from human adrenocortical cell line HAC15 (Gomez-Sanchez, C.E., et al. 2014 Mol. Cell. Endocrinol. 383(1-2):111-117).
Immunohistochemistry Analysis: A representative lot detected CYP11B1 in normal human adrenal tissue.
Jakość
Evaluated by Western Blotting in PC12 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected CYP11B1 in 10 µg of PC12 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected CYP11B1 in 10 µg of PC12 cell lysate.
Opis wartości docelowych
~52 kDa observed. Uncharacterized band(s) may appear in some lysates.
Postać fizyczna
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Przechowywanie i stabilność
Stable for 1 year at 2-8°C from date of receipt.
Inne uwagi
Concentration: Please refer to lot specific datasheet.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
This page may contain text that has been machine translated.
Nie możesz znaleźć właściwego produktu?
Wypróbuj nasz Narzędzie selektora produktów.
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Xilin Wu et al.
Nature medicine, 29(1), 190-202 (2023-01-17)
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery. However, the invasive nature of the standard pre-surgical investigation contributes to fewer than 1% of
Yanfei Mao et al.
Frontiers in endocrinology, 11, 593179-593179 (2021-01-26)
The majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). The therapeutic effect of dexamethasone may be related to its ability to improve cortical function. Recent study showed that dexamethasone can reduce COVID-19 deaths by up
Chang Ho Ahn et al.
Clinical endocrinology, 96(1), 30-39 (2021-11-08)
Primary aldosteronism (PA) shows histological heterogeneity and clinical variability, including the coexistence of hypercortisolemia. Immunohistochemical analyses of steroidogenic enzymes in adrenal tissues have provided new insights into the pathogenesis of PA. However, a comprehensive analysis of the association between enzyme
Junhua Zhou et al.
Nature genetics, 53(9), 1360-1372 (2021-08-14)
Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement for codriver mutations in APAs. Here we identified gain-of-function mutations in both CTNNB1
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej