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MABN50

Sigma-Aldrich

Anti-OLIG2 Antibody

mouse monoclonal, 211F1.1

Synonim(y):

oligodendrocyte lineage transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, human protein kinase C-binding protein RACK17, Protein kinase C-binding protein 2, protein kinase C binding protein 2, Class B basic helix-loop-helix pr

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Nazwa produktu

Anti-Olig2 Antibody, clone 211F1.1, clone 211F1.1, from mouse

pochodzenie biologiczne

mouse

Poziom jakości

forma przeciwciała

purified immunoglobulin

klon

211F1.1, monoclonal

reaktywność gatunkowa

mouse

reaktywność gatunkowa (przewidywana na podstawie homologii)

rat (based on 100% sequence homology), human (based on 100% sequence homology)

metody

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

izotyp

IgG2aκ

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... OLIG2(10215)

Opis ogólny

Oligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker.

Specyficzność

Anti-Olig2 Antibody recognizes Olig2.

Immunogen

Epitope: Unknown
Recombinant protein corresponding to human Olig2.

Zastosowanie

Detect Olig2 using this Anti-Olig2 Antibody, clone 211F1.1 validated for use in WB, IC, IH & IP.
Immunohistochemistry Analysis: This antibody has been shown to detect Olig2 in coronal brain tissue as reported by an independent laboratory (Cai, J., et al. (2007). Development. 134:1887-1899).

Immunocytochemistry Analysis: This antibody has been shown to detect Olig2, as reported by an independent laboratory (Lee, S.K., et al. (1995). Genes & Dev. 19:282-294).

Immunoprecipitation Analysis: This antibody has been shown to detect Olig2, as reported by an independent laboratory (Lee, S.K., et al. (1995). Genes & Dev. 19:282-294).
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Jakość

Evaluated by Western Blot in mouse brain lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected Olig2 on 10 µg of mouse brain lysate.

Opis wartości docelowych

~37 kDa observed

Postać fizyczna

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
Mouse brain lysate

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

An efficient and economical culture approach for the enrichment of purified oligodendrocyte progenitor cells.
Jianqin Niu,Lingyun Wang,Shubao Liu,Chengren Li,Jiming Kong,Hai-Ying Shen,Lan Xiao
Journal of Neuroscience Methods null
Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells.
Katsushima, K; Shinjo, K; Natsume, A; Ohka, F; Fujii, M; Osada, H; Sekido, Y; Kondo, Y
The Journal of Biological Chemistry null
Diverse behaviors of outer radial glia in developing ferret and human cortex.
Gertz, CC; Lui, JH; LaMonica, BE; Wang, X; Kriegstein, AR
The Journal of Neuroscience null
Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids.
Farioli-Vecchioli, S; Ceccarelli, M; Saraulli, D; Micheli, L; Cannas, S; D'Alessandro et al.
Frontiers in Cellular Neuroscience null
Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.
Clinton, SM; Glover, ME; Maltare, A; Laszczyk, AM; Mehi, SJ; Simmons, RK; King, GD
Brain Research null

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