MABN124

Anti-ATF-3 Antibody, clone 13A5.1

clone 13A5.1, from human(Recombinant)

• Synonim(y): Cyclic AMP-dependent transcription factor ATF-3, Activating transcription factor 3, cAMP-dependent transcription factor ATF-3
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: human (Recombinant)
• Poziom jakości: 100
• forma przeciwciała: purified antibody
• rodzaj przeciwciała: primary antibodies
• klon: 13A5.1, monoclonal
• reaktywność gatunkowa: mouse, human
• metody: western blot: suitable
• izotyp: IgG2bκ
• numer dostępu NCBI: NP_001665
• numer dostępu UniProt: P18847
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... ATF3(467)

Opis

Opis ogólny

Cyclic AMP-dependent transcription factor ATF-3 (UniProt P18847; also known as Activating transcription factor 3, cAMP-dependent transcription factor ATF-3) is encoded by the ATF3 gene (Gene ID 467) in human. ATF-3 belongs to the ATF/cAMP-responsive element-binding protein family of basic leucine zipper-type transcription factors. ATF-3 is markedly induced and functions as either a transcriptional activator or repressor in response to LPS, cytokines, hormones, DNA damage, and ER stress in various cell types. ATF3 plays key roles in atherosclerosis and hyperlipidemia, and is reported to negatively regulate the differentiation of adipocyte, chondrocyte, and osteoblast. ATF-3 dysfunction is closely related to various inflammatory diseases and cancer.

Specyficzność

Expected to react with spliced isoforms 1 and 5 (UniProt P18847-1 and P18847-5). Reactivity toward spliced isoforms 2, 3, and 4 (UniProt P18847-2 through P18847-4) of human ATF-3 has not been determined.

Immunogen

GST-tagged recombinant human ATF-3 fragment.

Zastosowanie

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of RAW264.7 cell lysate.

Jakość

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of THP-1 cell lysate.

Opis wartości docelowych

~19 kDa observed.

Postać fizyczna

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable